Recombinant Human Oncostatin M (HEK-293-expressed) Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Oncostatin M (OSM) is an approximately 30 KDa secreted cytokine belonging to the Interleukin-6 family. Like other members of the IL-6 family such as IL-11, CNTF, and Cardiotrophin-1, OSM plays crucial roles in inflammation, neuroprotection, hematopoiesis, metabolism and development (1). The human OSM cDNA encodes a 252 amino acid (aa) prepro protein with a signal peptide and a hydrophilic Cterminal domain that are proteolytically processed to generate the 195 aa mature form (2). Although both mature and pro-OSM are equally active in radioreceptor assays, the mature OSM is 5 to 60 fold more active in growth inhibition assays (3). Thus, proteolytic processing of the pro-OSM peptide may be important in regulating the in vivo activities of OSM (3). Cytokines of the IL-6 family share a common receptor subunit, gp130, which allows intracellular signal transduction. In contrast to other cytokines, OSM binds gp130 with very low affinity and has little to no biological activity unless a second receptor chain is recruited (4). The OSM-gp130 complex recruits either LIF R alpha, or OSM R beta to form the OSM receptor type I or OSM receptor type II respectively (5). Among multiples roles, OSM has been reported to modulate tumor cell and epithelial cell growth (6, 7). An axis involving OSM, CD40 Ligand and OSM receptor described as an antiviral and immunostimulatory system is disrupted in patients liver showing hepatitis C infection (8). Human OSM shares 45% aa sequence homology with mouse and rat OSM.

We have publications tested in 2 confirmed species: Human,  Human.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 2 of 2.

Publications using 8475-OM	Applications	Species
Kleuskens, MTA;Bek, MK;Al Halabi, Y;Blokhuis, BRJ;Diks, MAP;Haasnoot, ML;Garssen, J;Bredenoord, AJ;C A M van Esch, B;Redegeld, FA; Mast cells disrupt the function of the esophageal epithelial barrier Mucosal immunology 2023-06-09 [PMID: 37302713] (Cell Culture, Human)	Cell Culture	Human
M Parafati, RJ Kirby, S Khorasaniz, F Rastinejad, S Malany A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis Dis Model Mech, 2018-09-25;11(9):. 2018-09-25 [PMID: 30254132] (Bioassay, Human)	Bioassay	Human

Array 8475-OM

• Oncostatin M/OSM Antibodies
• Oncostatin M/OSM ELISA Kit
• Oncostatin M/OSM Lysate
• Oncostatin M/OSM Proteins
• Oncostatin M/OSM ELISAs
• Oncostatin M/OSM Proteins and Enzymes