Recombinant Human MCAM/CD146 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Melanoma cell adhesion molecule (MCAM), also known as MUC18 or CD146, is a putative adhesion molecule that belongs to the immunoglobulin superfamily (IgSF) (1). MCAM is an approximately 113 kDa type I transmembrane glycoprotein that contains a 536 amino acid (aa) extracellular domain (ECD), a 24 aa transmembrane domain, and a 63 aa cytoplasmic domain. Two MCAM splice variants have been observed, which vary in the length of their cytoplasmic tail (2). The ECD of human MCAM contains 2 IgV and 3 IgC2 domains and shares 74% and 73% identity with mouse and rat, respectively. MCAM was originally described as a marker of malignant potential in melanoma and was reported to promote both invasion and metastasis (3). Since then, expression has been detected in endothelial cells throughout the body and MCAM has been shown to be involved multiple cellular events including adhesion, migration, proliferation and differentiation (4, 5). Additionally, MCAM has been implicated in recruitment of activated T cells to inflammatory sites and is up-regulated in various inflammatory diseases (5, 6). Inhibiting MCAM signaling has been suggested as a potential therapy for diverse diseases including inflammatory bowel disease and ovarian cancer (7, 8). As a cellular adhesion molecule (CAM), MCAM functions as a molecular mediator to facilitate inter-cellular interactions of homotypic or heterotypic cells, or to intervene in interactions of cell-to-extracellular matrix for responding to physiological signal (9). MCAM has also been shown to be the functional ligand for Galectin-3 on endothelial cell surfaces (9).

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 2 of 2.

Publications using 9709-MA	Applications	Species
AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy Investigative Ophthalmology & Visual Science, 2021-07-01;62(9):32. 2021-07-01 [PMID: 34293080] (Bioassay, In Vivo, Human, Rat)	Bioassay, In Vivo	Human, Rat
Malara N, Trunzo V, Musolino G, Aprigliano S, Rotta G, Macrina L, Limongi T, Gratteri S, Di Fabrizio E, Renzulli A, Fini M, Mollace V Soluble CD54 induces human endothelial cells ex vivo expansion useful for cardiovascular regeneration and tissue engineering application. Int J Cardiol Heart Vasc, 2015-01-09;6(0):48-53. 2015-01-09 [PMID: 28785626]

Array 9709-MA

• MCAM/CD146 Antibodies
• MCAM/CD146 Antibody Pair
• MCAM/CD146 Protein
• MCAM/CD146 Proteins and Enzymes
• MCAM/CD146 ELISA