Name: Recombinant Human IL-22 Protein
Brand: Novus Biologicals
SKU: 782-IL
Price: 396 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Bioactivity

Additional Information	E. coli
Details of Functionality	Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. Nagalakshmi, M.L. et al. (2004) International Immunopharmacology 4:679. The ED₅₀ for this effect is 60-300 pg/mL.
Source	E. coli-derived human IL-22 protein Ala34-Ile179, with an N-terminal Met
Accession #	Q9GZX6
N-terminal Sequence	Met
Protein/Peptide Type	Recombinant Proteins
Gene	IL22
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Publications using 782-IL	Applications	Species
C Maresca, G Di Maggio, C Stolfi, F Laudisi, M Colella, T Pacifico, A Di Grazia, D Di Fusco, D Congiu, AM Guida, G Sica, I Monteleone, G Monteleone Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells Cancers, 2022-10-12;14(20):. 2022-10-12 [PMID: 36291778] (Stimulation, Human)	Stimulation	Human
S Segarra, T Naiken, J Garnier, V Hamon, N Coussay, FX Bernard Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract Oncogene, 2022-06-27;9(7):. 2022-06-27 [PMID: 35878340] (Bioassay, Human)	Bioassay	Human
DJ Carroll, MWN Burns, L Mottram, DC Propheter, A Boucher, GM Lessen, A Kumar, SA Malaker, C Xing, LV Hooper, U Yrlid, JJ Kohler Interleukin-22 regulates B3GNT7 expression to induce fucosylation of glycoproteins in intestinal epithelial cells The Journal of Biological Chemistry, 2021-12-02;0(0):101463. 2021-12-02 [PMID: 34864058] (Bioassay, Human)	Bioassay	Human
L Mercurio, M Morelli, C Scarponi, GL Scaglione, S Pallotta, C Albanesi, S Madonna PI3Kdelta Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis Cells, 2021-10-02;10(10):. 2021-10-02 [PMID: 34685616] (Stimulation, Human)	Stimulation	Human
F Abdallah, E Henriet, A Suet, A Arar, R Clemençon, JM Malinge, G Lecellier, P Baril, C Pichon miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response Cells, 2021-09-26;10(10):. 2021-09-26 [PMID: 34685526] (Stimulation, Human)	Stimulation	Human
HC Hawerkamp, A Domdey, L Radau, P Sewerin, P Oláh, B Homey, S Meller Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation Arthritis Research & Therapy, 2021-05-21;23(1):144. 2021-05-21 [PMID: 34020693] (Bioassay, Human)	Bioassay	Human
HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway Arthritis Research & Therapy, 2020-09-23;22(1):222. 2020-09-23 [PMID: 32972460] (Human)		Human
EY Kim, HM Noh, B Choi, JE Park, JE Kim, Y Jang, HK Lee, EJ Chang Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet Cells, 2019-12-06;8(12):. 2019-12-06 [PMID: 31817755] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
X Xu, H Fukui, Y Ran, X Wang, Y Inoue, N Ebisudani, H Nishimura, T Tomita, T Oshima, J Watari, H Kiyama, H Miwa The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues Mediators Inflamm., 2019-11-06;2019(0):7859460. 2019-11-06 [PMID: 31780871] (Bioassay, Human)	Bioassay	Human
KD Hebert, N Mclaughlin, M Galeas-Pen, Z Zhang, T Eddens, A Govero, JM Pilewski, JK Kolls, DA Pociask Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection Mucosal Immunol, 2019-10-09;0(0):. 2019-10-09 [PMID: 31597930] (Bioassay, Human)	Bioassay	Human
JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models Cells, 2019-09-15;8(9):. 2019-09-15 [PMID: 31540162] (Bioassay, Human)	Bioassay	Human
S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane TNF-Î± and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes J. Dermatol. Sci., 2019-08-21;0(0):. 2019-08-21 [PMID: 31501002] (Cell Culture, Human)	Cell Culture	Human
H Lindahl, AO Guerreiro-, SK Bedri, M Linnerbaue, M Lindén, N Abdelmagid, K Tandre, C Hollins, L Irving, C Glover, C Jones, L Alfredsson, L Rönnblom, I Kockum, M Khademi, M Jagodic, T Olsson IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis J. Immunol., 2019-07-10;0(0):. 2019-07-10 [PMID: 31292217] (Cell Culture, Human)	Cell Culture	Human
S Sun, X Zhang, M Xu, F Zhang, F Tian, J Cui, Y Xia, C Liang, S Zhou, H Wei, H Zhao, G Wu, B Xu, X Liu, G Yang, Q Wang, L Zhang, Y Gong, C Shao, Y Zou Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes Cell Death Dis, 2019-03-20;10(4):274. 2019-03-20 [PMID: 30894513] (Bioassay, Human)	Bioassay	Human
F Abdallah, G Lecellier, P Raharivelo, C Pichon R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferation Sci Rep, 2019-03-11;9(1):4132. 2019-03-11 [PMID: 30858525] (Bioassay, Human)	Bioassay	Human
JE Heath, GM Scholz, PD Veith, EC Reynolds IL-36? regulates mediators of tissue homeostasis in epithelial cells Cytokine, 2019-03-08;119(0):24-31. 2019-03-08 [PMID: 30856602] (Bioassay, Human)	Bioassay	Human
L Mercurio, M Morelli, C Scarponi, EZ Eisenmesse, N Doti, G Pagnanelli, E Gubinelli, C Mazzanti, A Cavani, M Ruvo, CA Dinarello, C Albanesi, S Madonna IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment Cell Death Dis, 2018-10-30;9(11):1104. 2018-10-30 [PMID: 30377293] (Bioassay, Human)	Bioassay	Human
M Abikhair B, N Roudiani, J Chen, AL Santana, N Doudican, C Proby, D Felsen, JA Carucci Ruxolitinib inhibits cyclosporine-induced proliferation of cutaneous squamous cell carcinoma JCI Insight, 2018-09-06;3(17):. 2018-09-06 [PMID: 30185657] (Bioassay, Human)	Bioassay	Human
BA Stanfield, PJF Rider, J Caskey, F Del Piero, KG Kousoulas Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses Vaccine, 2018-04-11;0(0):. 2018-04-11 [PMID: 29655629] (Cell Culture, Human)	Cell Culture	Human
L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum J. Allergy Clin. Immunol., 2018-01-31;0(0):. 2018-01-31 [PMID: 29371118] (Cell Culture, Human)	Cell Culture	Human
S Sawamura, M Jinnin, K Inoue, K Yamane, N Honda, I Kajihara, T Makino, S Masuguchi, S Fukushima, H Ihn Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts J. Dermatol. Sci., 2017-12-29;0(0):. 2017-12-29 [PMID: 29336866] (Bioassay, Human)	Bioassay	Human
S Abadpour, B Halvorsen, A Sahraoui, O Korsgren, P Aukrust, H Scholz Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT J. Mol. Endocrinol., 2018-01-12;0(0):. 2018-01-12 [PMID: 29330151] (Bioassay, Human)	Bioassay	Human
R Bichele, J Kärner, K Truusalu, I Smidt, R Mändar, HR Conti, SL Gaffen, P Peterson, M Laan, K Kisand IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model Eur. J. Immunol., 2017-12-11;0(0):. 2017-12-11 [PMID: 29150834] (Bioassay, Mouse)	Bioassay	Mouse
Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression J. Immunol., 2017-09-22;0(0):. 2017-09-22 [PMID: 28939759] (Bioassay, Human)	Bioassay	Human
M Tohyama, Y Shirakata, Y Hanakawa, X Dai, K Shiraishi, M Murakami, S Miyawaki, H Mori, R Utsunomiya, K Masuda, K Hashimoto, K Sayama Bcl-3 induced by IL-22 via STAT3 activation acts as a potentiator of psoriasis-related gene expression in epidermal keratinocytes Eur. J. Immunol., 2017-11-20;0(0):. 2017-11-20 [PMID: 28901004] (Bioassay, Human)	Bioassay	Human
E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis PLoS ONE, 2017-07-14;12(7):e0181486. 2017-07-14 [PMID: 28708859] (Bioassay, Human)	Bioassay	Human
Y Kim, J Lee, J Kim, CW Choi, YI Hwang, JS Kang, WJ Lee The pathogenic role of interleukin-22 and its receptor during UVB-induced skin inflammation PLoS ONE, 2017-05-30;12(5):e0178567. 2017-05-30 [PMID: 28558005] (Bioassay, Human)	Bioassay	Human
S La Manna, PL Scognamigl, C Di Natale, M Leone, FA Mercurio, AM Malfitano, F Cianfarani, S Madonna, S Caravella, C Albanesi, E Novellino, D Marasco Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces Biochimie, 2017-05-04;0(0):. 2017-05-04 [PMID: 28479106] (Bioassay, Surface Plasmon Resonance, Human)	Bioassay, Surface Plasmon Resonance	Human
J Zhang, IM Friberg, A Kift-Morga, G Parekh, MP Morgan, AR Liuzzi, CY Lin, KL Donovan, CS Colmont, PH Morgan, P Davis, I Weeks, DJ Fraser, N Topley, M Eberl Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections Kidney Int, 2017-03-17;0(0):. 2017-03-17 [PMID: 28318629] (ELISA (Standard))	ELISA (Standard)
JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? Proc. Natl. Acad. Sci. U.S.A, 2017-03-13;114(13):E2748-E2757. 2017-03-13 [PMID: 28289191] (Bioassay, Human)	Bioassay	Human
Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016-10-23;2016(0):4097574. 2016-10-23 [PMID: 27843200] (Bioassay, Human)	Bioassay	Human
JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages J Immunol, 2016-09-23;0(0):. 2016-09-23 [PMID: 27664279] (Bioassay, Human)	Bioassay	Human
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17 PLoS ONE, 2016-09-02;11(9):e0161759. 2016-09-02 [PMID: 27588419] (Bioassay, Human)	Bioassay	Human
The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis PLoS ONE, 2016-05-11;11(5):e0154904. 2016-05-11 [PMID: 27166675] (Bioassay, Human)	Bioassay	Human
OB Corneth, RM Reijmers, AM Mus, PS Asmawidjaj, JP van Hambur, N Papazian, JY Siegers, F Mourcin, R Amin, K Tarte, RW Hendriks, T Cupedo, E Lubberts Loss of IL-22 inhibits autoantibody formation in collagen-induced arthritis in mice Eur J Immunol, 2016-05-12;0(0):. 2016-05-12 [PMID: 27067635] (Bioassay, Human)	Bioassay	Human
Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier R Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes. J Neuroinflammation, 2015-06-16;12(0):119. 2015-06-16 [PMID: 26077779] (Bioassay, Human)	Bioassay	Human
Akil H, Abbaci A, Lalloue F, Bessette B, Costes L, Domballe L, Charreau S, Guilloteau K, Karayan-Tapon L, Bernard F, Morel F, Jauberteau M, Lecron J IL22/IL-22R pathway induces cell survival in human glioblastoma cells. PLoS ONE, 2015-03-20;10(3):e0119872. 2015-03-20 [PMID: 25793261] (Bioassay, Human)	Bioassay	Human
Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J The expression and regulation of chemerin in the epidermis. PLoS ONE, 2015-02-06;10(2):e0117830. 2015-02-06 [PMID: 25659101] (Bioassay, Human)	Bioassay	Human
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62. 2015-01-20 [PMID: 25604685] (Bioassay, Human)	Bioassay	Human
De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini M, Di Fusco D, Sica G, Sileri P, MacDonald T, Pallone F, Monteleone G, Stolfi C Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene, 2014-09-01;34(27):3493-503. 2014-09-01 [PMID: 25174402] (Bioassay, Human)	Bioassay	Human
Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, Ryan-Payseur B, Chen Z Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vgamma2Vdelta2 T cells after Mycobacterium tuberculosis infection or vaccination. Eur J Immunol, 2015-02-01;45(2):442-51. 2015-02-01 [PMID: 25141829] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))	Bioassay	Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014-07-10;9(7):e101937. 2014-07-10 [PMID: 25010647] (Bioassay, Human)	Bioassay	Human
Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto E, Ruma I, Inoue Y, Sakaguchi Y, Yamamoto K, Kinoshita R, Futami J, Kataoka K, Iwatsuki K, Huh N DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes. J Biol Chem, 2014-07-07;289(34):23389-402. 2014-07-07 [PMID: 25002577] (Bioassay, Human)	Bioassay	Human
Chen J, Wu M, Kuo S, Liao F IL-22 negatively regulates Helicobacter pylori-induced CCL20 expression in gastric epithelial cells. PLoS ONE, 2014-05-13;9(5):e97350. 2014-05-13 [PMID: 24824519] (Bioassay, Human)	Bioassay	Human
Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, Brand S Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS ONE, 2014-04-07;9(4):e93498. 2014-04-07 [PMID: 24710357] (Western Blot)	Western Blot
Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio P, Marasco D, Albanesi C Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses. Eur J Immunol, 2013-05-28;43(7):1883-95. 2013-05-28 [PMID: 23592500] (Bioassay, Human)	Bioassay	Human
Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 2013-03-18;190(8):3959-66. 2013-03-18 [PMID: 23509356] (Bioassay, Human)	Bioassay	Human
Pennino D, Bhavsar P, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham S, Cavani A, Eyerich K, Chung K, Schmidt-Weber C, Eyerich S IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients. J Allergy Clin Immunol, 2012-11-19;131(2):562-70. 2012-11-19 [PMID: 23174657] (Bioassay, Human)	Bioassay	Human
Ramirez-Carrozzi V, Sambandam A, Luis E IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol., 2011-10-12;12(12):1159-66. 2011-10-12 [PMID: 21993848] (Bioassay, Human)	Bioassay	Human
Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH TH17 cytokines induce human airway smooth muscle cell migration. J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2. 2011-02-22 [PMID: 21345484] (Bioassay, Human)	Bioassay	Human
Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression. J. Immunol., 2011-01-17;186(4):2613-22. 2011-01-17 [PMID: 21242515] (Bioassay, Human)	Bioassay	Human
Gudjonsson JE, Johnston A, Stoll SW Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 2010-04-08;130(7):1849-59. 2010-04-08 [PMID: 20376066] (Bioassay, Human)	Bioassay	Human
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis. J. Immunol., 2010-03-24;184(0):5263-70. 2010-03-24 [PMID: 20335534] (Bioassay, Human)	Bioassay	Human
Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med., 2010-02-01;207(2):299-308. 2010-02-01 [PMID: 20123959] (ELISA (Capture), Human)	ELISA (Capture)	Human
Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett., 2009-11-04;127(2):150-6. 2009-11-04 [PMID: 19895848] (ELISA (Standard))	ELISA (Standard)
Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol., 2009-12-01;39(12):3570-81. 2009-12-01 [PMID: 19830738] (Bioassay, Human)	Bioassay	Human
Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 2009-10-01;10(8):702-14. 2009-10-01 [PMID: 19798076] (Bioassay, Human)	Bioassay	Human
Tohyama M, Hanakawa Y, Shirakata Y, Dai X, Yang L, Hirakawa S, Tokumaru S, Okazaki H, Sayama K, Hashimoto K IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur. J. Immunol., 2009-10-01;39(10):2779-88. 2009-10-01 [PMID: 19731362] (Bioassay, Human)	Bioassay	Human
Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86. 2008-12-03 [PMID: 19056108] (Bioassay, Human)	Bioassay	Human
Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, Zaba LC, Cardinale I, Nograles KE, Khatcherian A, Novitskaya I, Carucci JA, Bergman R, Krueger JG Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis. J. Immunol., 2008-11-15;181(10):7420-7. 2008-11-15 [PMID: 18981165] (Bioassay, Human)	Bioassay	Human
Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med., 2008-02-10;14(3):275-81. 2008-02-10 [PMID: 18264110] (Bioassay, Human)	Bioassay	Human
Dambacher J, Beigel F, Zitzmann K, Heeg MH, Goke B, Diepolder HM, Auernhammer CJ, Brand S The role of interleukin-22 in hepatitis C virus infection. Cytokine, 2008-01-11;41(3):209-16. 2008-01-11 [PMID: 18191408] (Bioassay, Human)	Bioassay	Human
Sa SM, Valdez PA, Wu J The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol., 2007-02-15;178(4):2229-40. 2007-02-15 [PMID: 17277128] (Bioassay, Human)	Bioassay	Human
Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 2006-05-01;36(5):1309-23. 2006-05-01 [PMID: 16619290] (Bioassay, Human)	Bioassay	Human
Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol., 2003-11-15;171(10):5034-41. 2003-11-15 [PMID: 14607900] (Bioassay, Human)	Bioassay	Human
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Recombinant Human IL-22 Protein

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Catalog# & Formulation	Size	Price
Carrier Free 782-IL-010/CF

Gene Symbol	IL22
Uniprot	Q9GZX6()