Recombinant Human Glypican 4 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Glypican 4, also known as K-Glypican, is an approximately 220 kDa GPI-anchored heparan sulfate proteoglycan with a 60 kDa protein core (1, 2). It is expressed in brain, kidney, adrenal gland, and fat tissue (1, 3) and binds to basic FGF (2). Mature human Glypican 4 shares 97% and 96% amino acid (aa) sequence identity with mouse and rat Glypican 4, respectively. An alternative splice isoform lacks the N-terminal 70 aa including the signal peptide. In the developing brain, Glypican 4 is found in lateral ventricles surrounding the telencephalon, the dentate gyrus, proliferating neuroepithelial cells, and neural precursors (1, 2). It inhibits the dopaminergic differentiation of neurons (4). A 30 kDa cleaved form of Glypican 4 binds in cis to PTP sigma and contributes to excitatory synapse development and function (5). Glypican 4 is differentially expressed between adipose tissue depots (3). A soluble form can be released by adipocytes and circulates at elevated levels in obese patients with insulin resistance (3, 6). This form binds and enhances signaling through the Insulin R, and it also supports adipocyte differentiation (3). In zebrafish, Glypican 4 is required for cartilage formation and cardiomyocyte differentiation (7, 8).

We have publications tested in 3 confirmed species: Human, Mouse, N/A.

We have publications tested in 3 applications: Bioassay, ELISA Capture, Infrared Spectral Imaging.

Showing Publications 1 - 4 of 4.

Publications using 9195-GP	Applications	Species
Nakajima, C;Sawada, M;Umeda, E;Takagi, Y;Nakashima, N;Kuboyama, K;Kaneko, N;Yamamoto, S;Nakamura, H;Shimada, N;Nakamura, K;Matsuno, K;Uesugi, S;Vep?ek, NA;Küllmer, F;Nasufovi?, V;Uchiyama, H;Nakada, M;Otsuka, Y;Ito, Y;Herranz-Pérez, V;García-Verdugo, JM;Ohno, N;Arndt, HD;Trauner, D;Tabata, Y;Igarashi, M;Sawamoto, K; Identification of the growth cone as a probe and driver of neuronal migration in the injured brain Nature communications 2024-03-09 [PMID: 38461182] (Bioassay, Mouse)	Bioassay	Mouse
N Li, A Quan, D Li, J Pan, H Ren, G Hoeltzel, N de Val, D Ashworth, W Ni, J Zhou, S Mackay, SM Hewitt, R Cachau, M Ho The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer Nature Communications, 2023-04-08;14(1):1986. 2023-04-08 [PMID: 37031249] (ELISA Capture, Human)	ELISA Capture	Human
C Colin-Pier, V Untereiner, GD Sockalingu, L Ramont, S Brézillon Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle International Journal of Molecular Sciences, 2023-02-21;24(5):. 2023-02-21 [PMID: 36901723] (Infrared Spectral Imaging, N/A)	Infrared Spectral Imaging	N/A
GP Shelkar, PJ Gandhi, J Liu, SM Dravid Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens Science Advances, 2022-07-22;8(29):eabo6574. 2022-07-22 [PMID: 35867797] (Bioassay, Mouse)	Bioassay	Mouse

Array 9195-GP

• Glypican 4 Antibodies
• Glypican 4 ELISA Kits
• Glypican 4 Proteins
• Glypican 4 Proteins and Enzyme
• Glypican 4 ELISA