Recombinant Human BPI Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bactericidal/Permeability Increasing protein (BPI) is a 55 kDa antibacterial glycoprotein that plays a role in innate immunity (1, 2). It belongs to the lipid transfer protein family that also includes LPS binding protein (LBP), cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Circulating levels of BPI are positively correlated with the levels of cholesterol, LDL cholesterol, and HDL cholesterol (3). Mature human BPI shares approximately 55% amino acid (aa) sequence identity with mouse and rat BPI. It can be seceted as a monomer or as a disulfide‑linked homodimer (4). It consists of a highly basic N‑terminal and a hydrophobic C‑terminal domain (5). Its N‑terminal domain confers the ability of BPI to bind bacterial lipopolysaccharide (LPS) found in the cell walls of Gram negative bacteria and to induce the lysis and phagocytosis of these bacteria (6‑9). It also blocks the endothelial cell response to endotoxin (10). BPI is stored in neutrophil and eosinophil granules for induced secretion during inflammation (11, 12). It is additionally expressed in mucosal epithelia and testis (10, 13). BPI can be retained on the surface of both neutrophils and epithelial cells, presumably by its hydrophobic C‑terminal domain (8, 10). BPI also functions as an anti-angiogenic molecule by inhibiting vascular endothelial cell proliferation and tubule formation (14). Like the antibacterial actions, this function is mediated by the N‑terminal region (15).

We have publications tested in 3 confirmed species: Bacteria - E. Coli, Bacteria - Staphylococcus aureus, Yersinia pestis.

We have publications tested in 2 applications: Cell Culture, In Vivo.

Showing Publications 1 - 2 of 2.

Publications using 7468-BP	Applications	Species
SD Crane, SK Banerjee, KR Eichelberg, RC Kurten, WE Goldman, RD Pechous The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague Infection and Immunity, 2021-01-19;0(0):. 2021-01-19 [PMID: 33257531] (Cell Culture, Yersinia pestis)	Cell Culture	Yersinia pestis
V Deckert, S Lemaire, PJ Ripoll, JP de Barros, J Labbé, CC Borgne, V Turquois, G Maquart, D Larose, N Desroche, F Ménétrier, N Le Guern, LJ Lebrun, C Desrumaux, T Gautier, J Grober, C Thomas, D Masson, LM Houdebine, L Lagrost Recombinant human plasma phospholipid transfer protein (PLTP) to prevent bacterial growth and to treat sepsis Sci Rep, 2017-06-08;7(1):3053. 2017-06-08 [PMID: 28596518] (In Vivo, Bacteria - E. Coli, Bacteria - Staphylococcus aureus)	In Vivo	Bacteria - E. Coli, Bacteria - Staphylococcus aureus

Array 7468-BP

• BPI Antibodies
• BPI ELISA Kits
• BPI Lysate
• BPI Protein
• BPI Proteins and Enzyme
• BPI ELISA