Recombinant Human CD300f/LMIR3 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

LMIR3, also known as CD300f, CD300LF, IREM-1, CLM-1, IgSF13, DIgR1, and MAIR-V, is a 50‑60 kDa glycoprotein member of the immunoglobulin superfamily (1). Human LMIR3 consists of a 137 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane segment, and a 113 aa cytoplasmic domain that contains multiple immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or ITIM-like sequences (2, 3). Alternate splicing generates additional isoforms that carry substituted C-terminal tails of varying lengths and sequences following the ECD or transmembrane segment (3). Within the ECD, human LMIR3 shares 43% aa sequence identity with mouse and rat LMIR3. LMIR3 is expressed on the surface of dendritic cells, monocytes, granulocytes, and mast cells as well as on acute myeloid leukemia (AML) blasts (2-4). Pervanadate treatment or antibody cross‑linking of LMIR3 induces phosphorylation of tyrosine residues in the cytoplasmic domain and the subsequent recruitment of phosphatases SHIP, SHP-1, SHP-2, and the p85 alpha subunit of PI3K (2, 3, 5, 6). LMIR3 ligation can induce cell death and inhibit signaling through multiple receptors including Fc epsilon RI, LMIR4, SCF R, TLR2, TLR3, and TLR9 (3-8). In contrast, it enhances
TLR4‑mediated signaling/cytokine production in mast cells through association with the activating signaling protein FcR gamma (5). In mouse, a splice variant of LMIR3 (known as DIgR2, with a 7 aa insertion in the ECD) inhibits CD4⁺ T cell activation and in vivo Th1 and CTL responses (9). LMIR3 is up‑regulated on monocytes surrounding experimentally-induced spinal cord demyelination and functions as a negative regulator of inflammation in the CNS (10).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Cell Culture, Surface Plasmon Resonance (SPR.

Showing Publications 1 - 2 of 2.

Publications using 2774-LM	Applications	Species
VR Graziano, FC Walker, EA Kennedy, J Wei, K Ettayebi, MS Strine, RB Filler, E Hassan, LL Hsieh, AS Kim, AO Kolawole, CE Wobus, LC Lindesmith, RS Baric, MK Estes, RC Orchard, MT Baldridge, CB Wilen CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus PLoS Pathog., 2020-04-06;16(4):e1008242. 2020-04-06 [PMID: 32251490] (Cell Culture, Human)	Cell Culture	Human
P Papareddy, M Rossnagel, F Doreen Hol, G Kilic, S Veerla, C Naudin, E Smeds, J Westman, I Martinez-M, A Egesten, ME de la More, J Corral, A Linder, A Artoni, M Abbattista, C Novembrino, C Herbert Br, I Martinelli, G Kasetty, H Herwald A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection Nat Microbiol, 2019-09-23;0(0):. 2019-09-23 [PMID: 31548687] (Surface Plasmon Resonance (SPR, Human)	Surface Plasmon Resonance (SPR	Human

Array 2774-LM

• CD300f/LMIR3/CD300LF Antibodies
• CD300f/LMIR3/CD300LF ELISA Kits
• CD300f/LMIR3/CD300LF Lysate
• CD300f/LMIR3/CD300LF Protein
• CD300f/LMIR3/CD300LF Proteins and Enzymes