Recombinant Cynomolgus Monkey CD43 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD43, also known as Leukosialin and Sialophorin and Ly-48, is a type I transmembrane sialylated mucin that is expressed on most leukocytes and some tumor cells (1). Notably, the membrane expression of CD43 seems to be a characteristic of leukocytes, while cytoplasmic expression without membrane insertion occurs in endothelium and select epithelia. While CD43 restricts leukocyte adhesion and modulates T cell activation, these activities are context specific (2). CD43 can both induce and protect against apoptosis and can either promote or block cell adhesion (3). CD43 with altered glycosylations are expressed in cancers (4). The extracellular portion of cynomolgus monkey CD43 has a 78.2%, and 93.0% identity to human and rhesus monkeys, respectively.. CD43 induced cellular adhesion through the binding to molecules such as E-selectin (5, 6), galectin-1 and galectin-3 (7), siglec-1 (8), M-ficolin (9), integrins (10), cell surface nucleolin (11), and ICAM-1 (intercellular adhesion molecule type 1) (12). During cancer development, CD43 signalling induces the activation of 𝛽-catenin, NF-𝜅B (13, 14), NFAT, and AP-1, which are prosurvival transcription factors that can promote tumorigenesis when deregulated (15, 16).

Array 11205-CD

• CD43/Sialophorin Antibodies
• CD43/Sialophorin Lysates
• CD43/Sialophorin Proteins
• CD43/Sialophorin Proteins and Enzymes