Recombinant Canine Tie-2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Tie-2, also known as Angiopoietin-1 receptor and Tek, along with the closely related Tie1, are vascular-specific receptor tyrosine kinases (RTKs) involved in angiogenesis, vascular development, and hematopoiesis (1, 2). The Tie molecules are characterized by three immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains, and three fibronectin type III-like repeats in the extracellular domain (ECD) and a split tyrosine kinase domain in the cytoplasmic region (3, 4). The ECD of canine Tie-2 shares 94% amino acid sequence identity with human Tie-2. The ECD of human Tie-2 is known to be cleaved from the cell surface, releasing a ~75 kDa soluble Tie-2 (5).  Tie-2 is expressed primarily on endothelial and hematopoietic progenitor cells and plays central roles in both developmental and tumor-induced angiogenesis of the adult vascular system (6). Tie receptor signaling is modulated by angiopoietins (Ang), a family secreted, multimeric growth factor ligands (2). Tie-2 signaling is activated by Ang1 and inhibited by Ang2, whereas Tie1 is considered an orphan receptor with no known ligands (7). Tie-2 and Tie1 can form heteromeric complexes in cells that express both receptors and this complex might attenuate signaling from Tie-2 (1, 8, 9).  Tie-2 overexpression has been documented in breast, ovarian and hepatocellular tumors, as well as in glioblastomas and modulation of the Tie signaling pathway has been a target for the treatment of numerous diseases and cancers (10, 11).

Array 10720-T2

• Tie-2 Antibodies
• Tie-2 Antibody Pair
• Tie-2 Lysate
• Tie-2 Protein
• Tie-2 ELISAs
• Tie-2 Proteins and Enzymes