Species: Hu
Applications: WB, Simple Western, IHC, B/N
Host: Goat Polyclonal
Species: Mu, Rt
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, IHC, CyTOF-ready, Flow
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Host: Rabbit
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Binding Activity
Species: Hu
Applications: Bioactivity
Description
TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Mouse
|
| Product By Gene ID |
7010 |
| Alternate Names |
- angiopoietin-1 receptor
- CD202b antigen
- CD202B
- EC 2.7.10
- EC 2.7.10.1
- hTIE2
- p140 TEK
- soluble TIE2 variant 1
- soluble TIE2 variant 2
- TEK tyrosine kinase, endothelial
- TIE-2
- TIE2CD202b
- Tunica interna endothelial cell kinase
- Tyrosine-protein kinase receptor TEK
- Tyrosine-protein kinase receptor TIE-2
- venous malformations, multiple cutaneous and mucosal
- VMCM
- VMCM1
|
![Western Blot Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie2_AF313_Western_Blot_17326.jpg)
![Immunohistochemistry Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie2_AF762_Immunohistochemistry_24180.jpg)
![Western Blot Tie-2 [p Tyr992] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie-2_AF2720_Western_Blot_5212.jpg)
![Sandwich ELISA Tie-2 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/Tie-2-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79518-img0001.jpg)
![N/A Tie-2 [Biotin]](http://images.novusbio.com/fullsize2/DATA_Tie2_DY5159_ELISA_2083.jpg)
![N/A Tie-2 [HRP]](http://images.novusbio.com/fullsize2/DATA_Tie2_MTE200_ELISA_1038.jpg)
![Binding Activity Tie-2 [Unconjugated]](http://images.novusbio.com/fullsize2/Tie2_313TI_3068.jpg)
![Binding Activity Tie-2 [Biotin]](http://images.novusbio.com/fullsize2/avi10727_recombinant-human-tie-2-fc-chimera-avi-tag-protein-cf-binding-activity-2432021105025.jpg)
![Immunohistochemistry Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie-2_AF313_Immunohistochemistry_9366.jpg)
![Simple Western Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie2_AF313_Simple_Western_18668.jpg)
![Western Blot Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af762_mouse-rat-tie-2-affinity-purified-polyclonal-ab-8220249505990.jpg)
![Immunocytochemistry/ Immunofluorescence Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af762_mouse-rat-tie-2-affinity-purified-polyclonal-ab-8220249503278.jpg)
![Western Blot Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af762_mouse-rat-tie-2-affinity-purified-polyclonal-ab-8220249504643.jpg)
![Western Blot Tie-2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af762_mouse-rat-tie-2-affinity-purified-polyclonal-ab-4420241543319.jpg)
![Immunohistochemistry Tie-2 [p Tyr992] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie2_AF2720_Immunohistochemistry_24140.jpg)
![Intracellular Staining by Flow Cytometry Tie-2 [p Tyr992] Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Tie-2_AF2720_Flow_Cytometry_8182.jpg)
![Western Blot Tie-2 [p Tyr992] Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af2720_phospho-tie-2-y992-affinity-purified-polyclonal-ab-41202412403547.jpg)
![N/A Tie-2 [HRP]](http://images.novusbio.com/fullsize2/Tie-2_MTE200_ELISA_326.jpg)
![SDS-PAGE Tie-2 [Biotin]](http://images.novusbio.com/fullsize2/avi10727_recombinant-human-tie-2-fc-chimera-avi-tag-protein-cf-sds-page-2332021143342.jpg)