Podocalyxin Like Antibody (192703) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Podocalyxin, also known as Podocalyxin-like protein-1 (PCLP1 or PODXL), is a type I transmembrane glycoprotein. It belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology. Podocalyxin is a major sialoprotein in the podocytes of the kidney glomerulus and is also expressed by both endothelium and multipotent hematopoietic progenitors. It has been identified as a novel cell surface marker for hemangioblasts, the common precursors of hematopoietic and endothelial cells (1, 2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.

We have publications tested in 9 applications: Bioassay, Co-Immunoprecipitation, Flow Cytometry, ICC, IHC, IHC-Fr, Immunocytochemistry, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 39. Show All 39 Publications. Collapse Publications.

Publications using MAB1556	Applications	Species
Pedard, M;Prevost, L;Carpena, C;Holleran, B;Desrues, L;Dubois, M;Nicola, C;Gruel, R;Godefroy, D;Deffieux, T;Tanter, M;Ali, C;Leduc, R;Prézeau, L;Gandolfo, P;Morin, F;Wurtz, O;Bonnard, T;Vivien, D;Castel, H; The urotensin II receptor triggers an early meningeal response and a delayed macrophage-dependent vasospasm after subarachnoid hemorrhage in male mice Nature communications 2024-09-29 [PMID: 39341842] (Immunohistochemistry, Transgenic Mouse)	Immunohistochemistry	Transgenic Mouse
Despin-Guitard, E;Rosa, VS;Plunder, S;Mathiah, N;Van Schoor, K;Nehme, E;Merino-Aceituno, S;Egea, J;Shahbazi, MN;Theveneau, E;Migeotte, I; Non-apical mitoses contribute to cell delamination during mouse gastrulation Nature communications 2024-08-28 [PMID: 39198421] (Immunocytochemistry, Mouse)	Immunocytochemistry	Mouse
Schumacher, S;Fernkorn, M;Marten, M;Chen, R;Kim, YS;Bedzhov, I;Schröter, C; Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation Nature communications 2024-06-13 [PMID: 38871742] (Immunocytochemistry, Human)	Immunocytochemistry	Human
de Melo GD, Perraud V, Alvarez F et al. Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants Nature communications 2023-07-26 [PMID: 37495586]
Huang B, Zeng Z, Li H et al. Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids bioRxiv 2023-05-26 [PMID: 37293038]
Hatice O. Ozguldez, Niraimathi Govindasamy, Rui Fan, Hongyan Long, Karina Mildner, Dagmar Zeuschner et al. Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage Cell Reports 2023-04-01 [PMID: 36989113]
Xuan Liang, Antonia Weberling, Chun Yuan Hii, Magdalena Zernicka‐Goetz, Clare E Buckley E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities The EMBO Journal 2022-12-15 [PMID: 35993232]
Brittney J. Brown, Kimber L. Boekell, Brian R. Stotter, Brianna E. Talbot, Johannes S. Schlondorff Gain-of-function, focal segmental glomerulosclerosis Trpc6 mutation minimally affects susceptibility to renal injury in several mouse models PLOS ONE 2022-08-01 [PMID: 35913909]
Neelika Roy Chowdhury, Isabel Hopp, Peter Zilm, Patricia Murray, Krasimir Vasilev Silver nanoparticle modified surfaces induce differentiation of mouse kidney-derived stem cells† RSC Advances 2018-05-30 [PMID: 35541676]
L Karsten, N Janson, V Le Joncour, S Alam, B Müller, J Tanjore Ra, P Laakkonen, N Sewald, KM Müller Bivalent EGFR-Targeting DARPin-MMAE Conjugates International Journal of Molecular Sciences, 2022-02-23;23(5):. 2022-02-23 [PMID: 35269611] (IHC, Mouse)	IHC	Mouse
R Halimi, S Levin-Zaid, V Levin-Salo, S Bialik, A Kimchi Epiblast fragmentation by shedding-a novel mechanism to eliminate cells in post-implantation mouse embryos Cell Death and Differentiation, 2022-01-07;0(0):. 2022-01-07 [PMID: 34992231] (IHC, Mouse)	IHC	Mouse
J Langkabel, A Horne, L Bonaguro, L Holsten, T Hesse, A Knaus, Y Riedel, M Becker, K Händler, T Elmzzahi, K Bassler, N Reusch, LH Yeghiazari, T Pecht, A Saglam, T Ulas, AC Aschenbren, F Kaiser, C Kubaczka, JL Schultze, H Schorle Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs Nature Communications, 2021-12-16;12(1):7322. 2021-12-16 [PMID: 34916498] (ICC, Mouse)	ICC	Mouse
Kirill Salewskij, Theresa Gross‐Thebing, Elizabeth Ing‐Simmons, Binyamin Duethorn, Bettina Rieger, Rui Fan et al. Ronin governs the metabolic capacity of the embryonic lineage for post‐implantation development EMBO reports 2021-11-04 [PMID: 34515391]
P Filppu, JT Ramanathan, KJ Granberg, E Gucciardo, H Haapasalo, K Lehti, M Nykter, V Le Joncour, P Laakkonen CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity JCI Insight, 2021-05-10;6(9):. 2021-05-10 [PMID: 33986188] (Co-Immunoprecipitation, ICC, Western Blot, Mouse)	Co-Immunoprecipitation, ICC, Western Blot	Mouse
MA Molè, A Weberling, R Fässler, A Campbell, S Fishel, M Zernicka-G Integrin &beta1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition Cell Reports, 2021-03-09;34(10):108834. 2021-03-09 [PMID: 33691117] (ICC, IHC, Mouse)	ICC, IHC	Mouse
A Weberling, M Zernicka-G Trophectoderm mechanics direct epiblast shape upon embryo implantation Cell Reports, 2021-01-19;34(3):108655. 2021-01-19 [PMID: 33472064] (IHC, Human, Mouse)	IHC	Human, Mouse
Gianluca Amadei, Kasey Y.C. Lau, Joachim De Jonghe, Carlos W. Gantner, Berna Sozen, Christopher Chan et al. Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro Developmental Cell 2021-02-08 [PMID: 33378662]
R Fan, YS Kim, J Wu, R Chen, D Zeuschner, K Mildner, K Adachi, G Wu, S Galatidou, J Li, HR Schöler, SA Leidel, I Bedzhov Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause Nat Commun, 2020-10-30;11(1):5499. 2020-10-30 [PMID: 33127892] (ICC, IHC, Mouse)	ICC, IHC	Mouse
Li B, Zhu C, Dong L et al. ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling J. Pathol. 7/27/2020 [PMID: 32715474]
S Singla, LK Iwamoto-St, M Zhu, M Zernicka-G Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism Nat Commun, 2020-06-11;11(1):2958. 2020-06-11 [PMID: 32528010] (IHC, Mouse)	IHC	Mouse
C Kyprianou, N Christodou, RS Hamilton, W Nahaboo, DS Boomgaard, G Amadei, I Migeotte, M Zernicka-G Basement membrane remodelling regulates mouse embryogenesis Nature, 2020-05-06;582(7811):253-258. 2020-05-06 [PMID: 32523119] (IHC, Mouse)	IHC	Mouse
A Neagu, E van Gender, I Escudero, L Verwegen, D Kurek, J Lehmann, J Stel, RAM Dirks, G van Mierlo, A Maas, C Eleveld, Y Ge, AT den Dekker, RWW Brouwer, WFJ van IJcken, M Modic, M Drukker, JH Jansen, NC Rivron, EB Baart, H Marks, D Ten Berge In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states Nat. Cell Biol., 2020-05-04;22(5):534-545. 2020-05-04 [PMID: 32367046] (Bioassay, Mouse)	Bioassay	Mouse
Sozen B, Cox AL, De Jonghe J, et al. Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid Dev. Cell 12/16/2019 [PMID: 31846649]
D Zhou, H Fu, Y Han, L Zhang, S Liu, L Lin, DB Stolz, Y Liu Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis JCI Insight, 2019-11-14;4(22):. 2019-11-14 [PMID: 31647783] (IHC, Western Blot, Rat)	IHC, Western Blot	Rat
Neophytos Christodoulou, Antonia Weberling, Douglas Strathdee, Kurt I. Anderson, Paul Timpson, Magdalena Zernicka-Goetz Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation Nature Communications 2019-08-07 [PMID: 31391456]
Vivek Kasinath, Osman Arif Yilmam, Mayuko Uehara, Merve Yonar, Liwei Jiang, Xiaofei Li et al. Urine podoplanin heralds the onset of ischemia-reperfusion injury of the kidney American Journal of Physiology-Renal Physiology 5/1/2019 [PMID: 30864839]
N Christodou, C Kyprianou, A Weberling, R Wang, G Cui, G Peng, N Jing, M Zernicka-G Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation Nat. Cell Biol., 2018-10-15;0(0):. 2018-10-15 [PMID: 30323188] (IHC, Mouse)	IHC	Mouse
N Naiman, K Fujioka, M Fujino, MT Valerius, SS Potter, AP McMahon, A Kobayashi Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development Dev. Cell, 2017-05-22;41(4):349-365.e3. 2017-05-22 [PMID: 28535371] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Susan K. Legan, Daniel D. Lee, Margaret A. Schwarz alpha 5 beta 1 integrin mediates pulmonary epithelial cyst formation Developmental Dynamics 2017-06-01 [PMID: 28370666]
Deborah A. Goldspink, Chris Rookyard, Benjamin J. Tyrrell, Jonathan Gadsby, James Perkins, Elizabeth K. Lund et al. Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres Open Biology 2017-02-08 [PMID: 28179500]
Guodong Huang, Bingyu Zou, Jianzhen Lv, Tongyu Li, Guoli Huai, Shaowei Xiang et al. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway International Journal of Molecular Medicine 2017-03-01 [PMID: 28112381]
Katsumi Fumoto Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition Development, 2016-12-02;0(0):. 2016-12-02 [PMID: 27913639] (IHC, Mouse)	IHC	Mouse
Kenichi Sakamoto, Kyoko Kuno, Minoru Takemoto, Peng He, Takahiro Ishikawa, Shunichiro Onishi et al. Pituitary Adenylate Cyclase-Activating Polypeptide Protects Glomerular Podocytes from Inflammatory Injuries Journal of Diabetes Research 2015-03-02 [PMID: 25821833]
Chuang P, Xu J, Dai Y, Jia F, Mallipattu S, Yacoub R, Gu L, Premsrirut P, He J In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells. Am J Pathol, 2014-07-01;184(7):1940-56. 2014-07-01 [PMID: 24952428] (IHC, Mouse)	IHC	Mouse
Ivan Bedzhov, Magdalena Zernicka-Goetz Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation Cell 2014-02-27 [PMID: 24529478]
Masaya Koshizaka, Minoru Takemoto, Seiya Sato, Hirotake Tokuyama, Masaki Fujimoto, Emiko Okabe et al. An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice Experimental Diabetes Research 2012-01-29 [PMID: 22319521]
Norman Sachs, Nike Claessen, Jan Aten, Maaike Kreft, Gwendoline J.D. Teske, Anneke Koeman et al. Blood pressure influences end-stage renal disease of Cd151 knockout mice Journal of Clinical Investigation 2012-01-03 [PMID: 22201679]
Maltby S, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery. Exp. Hematol., 2008-11-11;37(1):10-8. 2008-11-11 [PMID: 19004540] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Meyer TN, Schwesinger C, Wahlefeld J, Dehde S, Kerjaschki D, Becker JU, Stahl RA, Thaiss F A new mouse model of immune-mediated podocyte injury. Kidney Int., 2007-07-25;72(7):841-52. 2007-07-25 [PMID: 17653132] (Western Blot, Mouse)	Western Blot	Mouse
Show All 39 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Michelle Tallquist	IHC-Fr	Mouse	02/03/2017	View Summary Application Immunohistochemistry-Frozen Sample Tested 10 um fixed frozen mouse kidney Species Mouse Lot ipf0213071 Comments Comments 1) Adult mouse kidney was fixed for 1 hour in 4% paraformaldehyde at room temperature. Cryopreserved in sucrose, immersed in OCT and stored at -80C, then sectioned. 2)     Permeabilized with 0.1% Triton-X for 30min at room temp. 3)     Blocked in blocking buffer for 1hour at room temp. a.     1% BSA; 1.5% NDS ; 0.1% triton-x 4)     Anti-podocalyxin ab(rat) 5ug/ml [diluted in blocking buffer] for O/N in 4C
	5 reviewed by: Verified Customer	IHC-Fr	Mouse	02/10/2015	View Summary Application Immunohistochemistry-Frozen Sample Tested See PMID 23095233 Species Mouse

Array MAB1556

• Podocalyxin Like Antibodies
• Podocalyxin Like ELISA Kits
• Podocalyxin Like Lysate
• Podocalyxin Like Proteins
• Podocalyxin Like Proteins and Enzymes