Plexin B1 Antibody (559830)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Plexin B1 is a 300 kDa member of the B subfamily, Plexin family of Semaphorin receptors. Mature human Plexin B1 is a 2116 amino acid type I transmembrane (TM) glycoprotein that contains a 1471 aa extracellular domain (ECD) and a 612 aa cytoplasmic region. The ECD contains one Semaphorin domain, two PSI domains, and three IPT repeats. The ECD is cleaved into two subunits, a 200 kDa alpha -chain (aa 20-1305) and a 100 kDa TM beta -chain. The subunits are nondisulfide-linked and generate a high-affinity receptor. Plexin B1 is a receptor for Semaphorin 4D/CD100. It forms a receptor complex with neuropilins, MET, and EGF R2. Of three known splice variants, one shows a deletion of aa 689-871, a second shows a 53 aa substitution for aa 677‑2135, and a third shows a 53 aa substitution for the 53 aa between aa 677‑729. Over aa 35-150, human Plexin B1 shares 90% and 97% aa sequence identity with dog and mouse Plexin B1, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Functional Assay.

Showing Publication 1 - 1 of 1.

Publication using MAB37491	Applications	Species
EE Evans, V Mishra, C Mallow, EM Gersz, L Balch, A Howell, C Reilly, ES Smith, TL Fisher, M Zauderer Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity Journal of Neuroinflammation, 2022-08-06;19(1):200. 2022-08-06 [PMID: 35933420] (Functional Assay, Mouse)	Functional Assay	Mouse

Array MAB37491

• Plexin B1 Antibodies
• Plexin B1 ELISA Kits
• Plexin B1 Lysate
• Plexin B1 Protein
• Plexin B1 Proteins and Enzymes