PITX2 Antibody (2G6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 7 of 7.

Publications using H00005308-M01	Applications	Species
Chen, ZS;Ou, M;Taylor, S;Dafinca, R;Peng, SI;Talbot, K;Chan, HYE; Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/?-catenin pathway in C9ALS/FTD Nature communications 2023-12-18 [PMID: 38110419]
Mary W, Nicole G, Jessica B et al. TWIST1, a gene associated with Saethre-Chotzen syndrome, regulates extraocular muscle organization in mouse. Dev Biol. 2022-08-06 [PMID: 35944701]
Christian O, Jessika M, Rebecca G et al. Mechanotransductive Differentiation of Hair Follicle Stem Cells Derived from Aged Eyelid Skin into Corneal Endothelial-Like Cells. Stem Cell Rev Rep. 2021-09-13 [PMID: 34515937]
Lovatt M, Yam GH, Peh GS et al. Directed differentiation of periocular mesenchyme from human embryonic stem cells. Differentiation 2017-11-16 [PMID: 29239730]
Strungaru MH, Footz T, Liu Y et al. PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3. Invest Ophthalmol Vis Sci. 2011-08-27 [PMID: 21873665]
Acharya M, Lingenfelter DJ, Huang L et al. Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells. J Biol Chem 284(50):34829-38. 2009-12-11 [PMID: 19801652]
Amen, M, H M Espinoza et al. Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/{beta}-catenin signaling. Nucleic Acids Research 36: 462-476. 2008-01-01 [PMID: 18045789] (WB)	WB

Array H00005308-M01

• PITX2 Antibodies
• PITX2 Lysates
• PITX2 Proteins