PERK Antibody

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at Tyrosine 204 and 187 and Threonine 177 and 160 residues mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Threonine 202 and Tyrosine 204 residues of ERK 1 and Threonine 185 and Tyrosine 187 residues of ERK 2 is required for full enzymatic activation. The structural consequences of dual phosphorylation in ERK 2 include active site closure, alignment of key catalytic residues that interact with ATP, and remodeling of the activation loop. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Chicken.

We have publications tested in 3 applications: ICC/IF, IHC-P, WB.

Showing Publications 1 - 3 of 3.

Publications using NBP1-80930	Applications	Species
Qin L, Vetreno RP, Crews FT NADPH oxidase and endoplasmic reticulum stress is associated with neuronal degeneration in orbitofrontal cortex of individuals with alcohol use disorder Addiction biology 2023-01-01 [PMID: 36577732] (IHC-P, Human)	IHC-P	Human
Yao J, Ma Y, Lin X et al. The Attenuating Effect of the Intraovarian Bone Morphogenetic Protein 4 on Age-Related Endoplasmic Reticulum Stress in Chicken Follicular Cells Oxid Med Cell Longev 2020-06-08 [PMID: 32587659] (WB, Chicken)	WB	Chicken
Miri Jwa, Paul Chang. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1alpha-mediated unfolded protein response. Nature Cell Biology 2012-01-01 [PMID: 23103912] (ICC/IF, Human)	ICC/IF	Human

Array NBP1-80930

• PERK Antibodies
• PERK Lysate
• PERK Protein