Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Patched 1/PTCH. The exact sequence is proprietary.
Localization
Membrane; Multi-pass membrane protein
Predicted Species
Mouse (100%), Rat (100%), Chicken (100%), Xenopus (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTCH1
Purity
Antigen Affinity-purified
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161 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NBP2-19705 in the following applications:
Mink reactivity reported in scientific literature (PMID: 29030089). Xenopus laevis (100%).
Packaging, Storage & Formulations
Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol
Preservative
0.01% Thimerosal
Purity
Antigen Affinity-purified
Alternate Names for Patched 1/PTCH Antibody
BCNS
BCNSFLJ42602
FLJ26746
HPE7
mes
NBCCS
patched (Drosophila) homolog
Patched 1
patched homolog (Drosophila)
patched homolog 1 (Drosophila)
patched homolog 1
protein patched homolog 1
PTC
ptc1
PTCH protein +12b
PTCH protein +4'
PTCH protein -10
PTCH
PTCH1
PTCH11
Background
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq]
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information go to www.P65Warnings.ca.gov.
Publications for Patched 1/PTCH Antibody (NBP2-19705)(1)
We have publications tested in 1 confirmed species: Mink.
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Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for Patched 1/PTCH Antibody (NBP2-19705). (Showing 1 - 1 of 1 FAQ).
I need a proven anti-human Ptch1 antibody that maps C-terminus of Ptch1 protein which is thus appropriate for all isoforms of human Ptch1 protein. Can you please suggest any which can be used for Western blotting?
NB100-41101 is expected to recognize all isoforms. NBP2-19705, NBP1-71662, 21130002, and NBP1-59455 should all suit your needs as well. Further details about each product can be found on their individual datasheets.
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