Patched 1/PTCH Antibody - BSA Free

Manufactured by Genomic Antibody Technology™. GAT FAQs

Patched 1 (PTCH1) acts as a receptor for SHH, IHH (indian hedgehog) and DHH (desert hedgehog) in SHH/sonic hedgehog signaling pathway which is critical in embryonic development, tissue patterning, and cell-fate decisions. SHH pathway activation is triggered by binding of SHH to PTCH1 (glycosylation being necessary for binding), which in the absence of SHH suppresses the activity of SMO (Smoothened protein), and this SHH- PTCH1 binding or mutational inactivation of PTCH1 relieves the inhibition of SMO culminating in the activation of one or more of GLI1 transcription factors that regulate the expression of downstream targets. PTCH1 mutations or its aberrant expression may leads to developmental defects and a cancer-prone phenotype. Mice partially deficient in functional PTCH1 exhibit developmental abnormalities that are comparable to those of nevoid basal cell carcinoma syndrome patients and additionally, these mice develop tumors such as medulloblastomas, rhabdomyosarcomas, and basal cell carcinomas following UV or ionizing radiation exposure. PTCH1 germline mutations in humans are responsible for nevoid basal cell carcinoma syndrome, also called Gorlin syndrome characterized by various developmental malformations and a high predisposition to skin basal cell carcinoma. Besides basal cell nevus syndrome (BCNS), defects in PTCH1 have been linked to sporadic basal cell carcinoma (BCC) and holoprosencephaly type 7 (HPE7).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 6 of 6.

Publications using NBP1-71662	Applications	Species
Cheng AY, Lan J, Lee CH Impaired Wnt/beta-catenin and protein patched homolog 1 signaling in extraocular sebaceous carcinoma: A clinical and histopathological study The Journal of dermatology 2022-03-22 [PMID: 35318716]
Li X, Wen W, Li P Et Al. Mitochondrial Protection and Against Glutamate Neurotoxicity via Shh/Ptch1 Signaling Pathway to Ameliorate Cognitive Dysfunction by Kaixin San in Multi-Infarct Dementia Rats Oxidative medicine and cellular longevity 2021-07-09 [PMID: 34306310] (WB)	WB
X Wang, X Li, T Wang, SP Wu, JW Jeong, TH Kim, SL Young, BA Lessey, RB Lanz, JP Lydon, FJ DeMayo SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh Nat Commun, 2018-10-24;9(1):4421. 2018-10-24 [PMID: 30356064]
Takeuchi Y, Kito A, Itoh S et al. Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling. Exp. Cell Res. 2018-10-15 [PMID: 30193838] (WB, Rat)	WB	Rat
M W, SP W, X W et al. Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biology of Reprouction. 1905-07-09 [PMID: 28203817] (Mouse)		Mouse
Jeng KS, Sheen IS, Jeng WJ et al. High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma. Onco Targets Ther 2013-12-27 [PMID: 24403838] (WB, Human)	WB	Human

Array NBP1-71662

• Patched 1/PTCH Antibodies
• Patched 1/PTCH Lysate
• Patched 1/PTCH Proteins