Park7/DJ-1 Antibody

PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 1 application: WB.

Showing Publications 1 - 8 of 8.

Publications using NB100-1194	Applications	Species
Sriram K, Lin GX, Jefferson AM et al. Biological effects of inhaled crude oil vapor V. Altered biogenic amine neurotransmitters and neural protein expression Toxicology and applied pharmacology 2022-06-21 [PMID: 35750205] (Rat)		Rat
Bitar MS, Liu C, Ziaei A et al. Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy Invest Ophthalmol Vis Sci. 2012-08-24 [PMID: 22836768] (WB, Human)	WB	Human
Deeg S, Gralle M, Sroka K et al. BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. J Cell Biol. 2010-02-22 [PMID: 20156966] (WB) Details: DJ-1 antibody western blot in the following figures. 1. Fig 1, transiently transfected wild type and mutant DJ-1 SH-SY5Y neuroblastoma cells, DJ-1 siRNA knockdown of endogenous DJ-1 SH-SY5Y cells, detection of DJ-1 following IP of BAG1 (results showed tha	WB
Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener;4:12. 2009-02-25 [PMID: 19243613]
Saito Y, Nishio K, Ogawa Y, Kimata J, Kinumi T, Yoshida Y, Noguchi N, Niki E. Turning point in apoptosis/necrosis induced by hydrogen peroxide. Free Radic Res;40(6):619-30. 2006-06-01 [PMID: 16753840]
Ooe H, Taira T, Iguchi-Ariga SM, Ariga H. Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. Toxicol Sci;88(1):114-26. 2005-11-01 [PMID: 16093527]
Willis D, Li KW, Zheng JQ, Chang JH, Smit A, Kelly T, Merianda TT, Sylvester J, van Minnen J, Twiss JL. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. J Neurosci;25(4):778-91. 2005-01-26 [PMID: 15673657]
Nagakubo D, Taira T, Kitaura H et al. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 1997-02-13 [PMID: 9070310]

Images	Ratings	Applications	Species	Date	Details
	3 reviewed by: Verified Customer	WB	Human	12/12/2014	View Summary Application Western Blot Sample Tested See PMID:22836768 Species Human

Array NB100-1194

• Park7/DJ-1 Antibodies
• Park7/DJ-1 Lysate
• Park7/DJ-1 Proteins
• Park7/DJ-1 ELISAs