p70 S6 Kinase/S6K Antibody

Ribosomal S6 kinase has two isoforms, termed S6K1 (S6Ka) and S6K2 (S6Kb). The S6K1 isoform has two splicing forms, which are the products of alternative start codon usage. The first splicing form, p70S6K or p70S6K1, has a predicted molecular mass of 56 kDa and an apparent molecular mass (SDS-PAGE) of 70 kDa. The second isoform, p85S6K or p85S6K1, contains 23 extra amino acid residues at the N terminus, resulting from the alternative start codon. It has a predicted molecular mass of 59 kDa and an apparent molecular mass of 85 kDa. Both, p70 and p85 S6K1 are activated by multiple S/T phosphorylations in response to various mitogenic stimuli and nutrients. This is accompanied by significant mobility shift in the migration of both forms, when analysed by SDS-PAGE electrophoresis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NB100-293	Applications	Species
Kumari R, Willing LB, Jefferson LS et al. REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade. Biochem Biophys Res Commun 2011-09-01 [PMID: 21856283]
Favier FB, Costes F, Defour A et al. Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia. Am J Physiol Regul Integr Comp Physiol 2010-06-01 [PMID: 20237300]
Corl BA, Odle J, Niu X et al. Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. J Nutr 2008-01-01 [PMID: 18156399]
Choong LY, Lim S, Loh MC et al. Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics. Mol Cancer Ther 2007-11-01 [PMID: 17989321]
Rhoads JM, Corl BA, Harrell R et al. Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis. Am J Physiol Gastrointest Liver Physiol 2007-03-01 [PMID: 17138969]
Rhoads JM, Niu X, Odle J et al. Role of mTOR signaling in intestinal cell migration. Am J Physiol Gastrointest Liver Physiol 2006-09-01 [PMID: 16710051]

Array NB100-293

• p70 S6 Kinase/S6K Antibodies
• p70 S6 Kinase/S6K ELISA Kit
• p70 S6 Kinase/S6K Lysate
• p70 S6 Kinase/S6K Proteins
• p70 S6 Kinase/S6K ELISAs
• p70 S6 Kinase/S6K Proteins and Enzyme