p70 S6 Kinase/S6K [p Thr421, p Ser424] Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

p70 S6 Kinase (p70S6K) is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues (1). p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6K activity undergoes changes in the cell cycle and increases
20-fold in G1 cells released from G0 (2). p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as T389, a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 6 of 6.

Publications using AF8965	Applications	Species
T Ueda, Y Kohama, H Sakurai IER family proteins are regulators of protein phosphatase PP2A and modulate the phosphorylation status of CDC25A Cell. Signal., 2018-12-30;0(0):. 2018-12-30 [PMID: 30599213] (Western Blot, Human)	Western Blot	Human
AE Shay, BT Diwakar, BJ Guan, V Narayan, JF Urban, KS Prabhu IL-4 upregulates cyclooxygenase-1 expression in macrophages J. Biol. Chem., 2017-07-06;0(0):. 2017-07-06 [PMID: 28684424] (Western Blot, Mouse)	Western Blot	Mouse
S Sakamoto, M Miyara, S Sanoh, S Ohta, Y Kotake Mild MPP(+) exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation Sci Rep, 2017-04-26;7(0):46668. 2017-04-26 [PMID: 28443637] (Western Blot, Human)	Western Blot	Human
Mir , Shakeel, Schwarze , Steven R, Jin , Ling, Zhang , Jinling, Friend , Woodrow, Miriyala , Sumitra, St Clair , Daret, Craven , Rolf J Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy, 2013-09-04;9(10):1566-78. 2013-09-04 [PMID: 24113030] (Western Blot, Human)	Western Blot	Human
Bradtmoller M, Hartmann C, Zietsch J, Jaschke S, Mautner V, Kurtz A, Park S, Baier M, Harder A, Reuss D, von Deimling A, Heppner F, Holtkamp N Impaired Pten expression in human malignant peripheral nerve sheath tumours. PLoS ONE, 2012-11-06;7(11):e47595. 2012-11-06 [PMID: 23139750] (Western Blot, Mouse)	Western Blot	Mouse
Nakai A, Yamaguchi O, Takeda T The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med., 2007-04-22;13(5):619-24. 2007-04-22 [PMID: 17450150] (Western Blot, Mouse)	Western Blot	Mouse

Array AF8965

• p70 S6 Kinase/S6K Antibodies
• p70 S6 Kinase/S6K ELISA Kit
• p70 S6 Kinase/S6K Lysate
• p70 S6 Kinase/S6K Proteins
• p70 S6 Kinase/S6K ELISAs
• p70 S6 Kinase/S6K Proteins and Enzyme