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Neuropilin-2 Antibody

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Immunohistochemistry-Paraffin: Neuropilin-2 Antibody [NBP1-86866] - Staining of human skeletal muscle shows weak positivity in myocytes.
Immunohistochemistry-Paraffin: Neuropilin-2 Antibody [NBP1-86866] - Staining of human skeletal muscle shows weak positivity in myocytes.
Immunohistochemistry-Paraffin: Neuropilin-2 Antibody [NBP1-86866] - Staining of human cerebral cortex shows moderate neuropil positivity
Immunohistochemistry-Paraffin: Neuropilin-2 Antibody [NBP1-86866] - Staining of human placenta shows moderate membranous positivity in trophoblastic cells.
Immunohistochemistry-Paraffin: Neuropilin-2 Antibody [NBP1-86866] - Staining of human smooth muscle shows moderate positivity.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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Neuropilin-2 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: LSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKEYL
Predicted Species
Mouse (96%), Rat (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NRP2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
Application Notes
IHC-P reported in scientific literature (PMID: 26199980). For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Neuropilin-2 Protein (NBP1-86866PEP)
Publications
Read Publication using
NBP1-86866 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Neuropilin-2 Antibody

  • MGC126574
  • neuropilin 2
  • Neuropilin2
  • Neuropilin-2
  • neuropilin-2a(22)
  • neuropilin-2b(0)
  • NP2
  • NPN 2
  • NPN2
  • PRO2714
  • receptor for VEGF165 and semaphorins class3
  • Vascular endothelial cell growth factor 165 receptor 2
  • vascular endothelial growth factor-165 receptor 2
  • VEGF1265R2
  • VEGF165R2neuropilin-2a(17)

Background

NRP2 encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Neuropilin-2 Antibody (NBP1-86866)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.


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IHC-P
(1)
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FAQs for Neuropilin-2 Antibody (NBP1-86866). (Showing 1 - 1 of 1 FAQ).

  1. Why are the bands shown in the WB different molecular weight? What is the correct size for nrp2? Are they isoforms? I think the dominant one will be 110 KD.
    • It is not the wrong WB image for the NBP1-86866 antibody. This antibody is designed from sequence information in the ENSEMBL database and according to the ENSEMBL database, there is an additional isoform of 62.5 kDa. The antigen of the NBP1-86866 antibody has 100% sequence identity to this isoform as well. The isoform is called NRP2-202 (ENSP00000347238) and consists of 555 amino acids (http://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;g=ENSG00000118257;r=2:206547224-206608421;t=ENST00000355117).

Secondary Antibodies

 

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Bioinformatics

Gene Symbol NRP2
Entrez
Uniprot