NCOA6 Antibody

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Block/Neutralize, IF/IHC, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using NB200-335	Applications	Species
Oh GS, Kim SR, Lee ES et al. Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6 Molecules and Cells 2022-04-30 [PMID: 35258009] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Kopanja D, Pandey A, Huang S et al. p19Arf Inhibits Aggressive Progression of H-ras driven Hepatocellular Carcinoma. Carcinogenesis 2017-12-08 [PMID: 29228217] (IF/IHC, Human)	IF/IHC	Human
Chen WD, Fu X, Dong B et al. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology 2012-10-01 [PMID: 22488010]
Vicent GP, Nacht AS, Font-Mateu J et al. Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation. Genes Dev 2011-04-01 [PMID: 21447625]
Lee S, Kim DH, Goo YH et al. Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation. Mol Endocrinol 2009-05-01 [PMID: 19221051]
Garapaty S, Xu CF, Trojer P et al. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem 2009-03-01 [PMID: 19131338]
Lee J, Saha PK, Yang QH et al. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A 2008-12-01 [PMID: 19047629]
Cho YW, Hong T, Hong S et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 2007-07-01 [PMID: 17500065]

Array NB200-335

• NCOA6 Antibodies
• NCOA6 Proteins