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MSH6 Antibody (CL13844)

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Staining of human breast cancer (ductal carcinoma) shows strong nuclear positivity in tumor cells.
Staining of human breast cancer (ductal carcinoma) shows strong nuclear positivity in tumor cells.
Staining of human skeletal muscle shows no positivity in myocytes as expected.
Staining of human ovarian cancer (high grade serous carcinoma) shows strong nuclear positivity in tumor cells.
Staining of human testis shows strong nuclear positivity in cells in seminiferous ducts.
Staining of human colon shows strong nuclear positivity in glandular cells.
Staining of human colorectal cancer shows strong nuclear positivity in tumor cells.
Western blot analysis in human cell line RH-30.
Orthogonal Strategies: Analysis in human testis and skeletal muscle tissues using NBP3-24582 antibody. Corresponding MSH6 RNA-seq data are presented for the same tissues.
Staining of human testis cancer (embryonal carcinoma) shows strong nuclear positivity in tumor cells.
Staining of human lymph node shows strong nuclear positivity in germinal center cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
CL13844
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

  

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MSH6 Antibody (CL13844) Summary

Immunogen
This antibody was designed to target the recombinant protein MSH6, with the precise immunogen sequence being withheld for proprietary reasons.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MSH6
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
  • Western Blot 1ug/ml
Application Notes
For IHC-Paraffin, we recommend using Heat-Induced Epitope Retrieval (HIER) with a pH level of 6. This optimized retrieval method ensures the best results for your experiments.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, 40% glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for MSH6 Antibody (CL13844)

  • DNA mismatch repair protein Msh6
  • G/T mismatch-binding protein
  • GTBPHNPCC5
  • GTMBP
  • hMSH6
  • HSAP
  • mutS (E. coli) homolog 6
  • mutS homolog 6 (E. coli)
  • MutS-alpha 160 kDa subunit
  • p160
  • sperm-associated protein

Background

MSH6 is a mismatch-repair protein. It plays a role in tumor suppression. Genomic mutations in MSH6 predispose to the hereditary non-polyposis colorectal cancer (HNPCC) syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for MSH6 Antibody (NBP3-24582). (Showing 1 - 1 of 1 FAQ).

  1. I am testing a mouse sample with human xenograft for GBM and I am looking for an MSH6 Antibody that will only detect the human cells.
    • Currently, we have no validation that any of our MSH6 antibodies will not cross react with mouse. All of our MSH6 Antibodies are raised against Human MSH6 so we have checked the % homology with mouse MSH6 which has come to be 85%. As 85% is very high, the chances of the antibody detecting the mouse tissue as well as the human tissue are high.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MSH6