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Mouse CCL2/JE/MCP-1 Quantikine ELISA Kit

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Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Mouse CCL2/JE/MCP-1 Quantikine ELISA Kit Summary

Background
The Quantikine® Mouse CCL2/JE/MCP-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse MCP-1 in cell culture supernates, tissue culture supernates, tissue lysates, serum, and plasma. It contains E. coli-expressed recombinant mouse MCP-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant... mouse MCP-1. Results obtained using natural mouse MCP-1 showed dose response curves that were parallel to the standard curves obtained using the Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse MCP-1.
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Specificity
Natural and recombinant mouse MCP-1.
Source
N/A
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
CCL2

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using
MJE00B in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL2/JE/MCP-1 Quantikine ELISA Kit

  • C-C motif chemokine ligand 2
  • CCL2
  • GDCF-2
  • HC11
  • HSMCR30
  • MCAF
  • Mcp1
  • MCP-1
  • SCYA2
  • SMC-CF

Background

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL2/JE/MCP-1 (MJE00B)(215)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.

We have publications tested in 2 applications: ELISA Capture, IHC.


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ELISA Capture
(3)
IHC
(1)
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Human
(1)
Mouse
(210)
Rat
(2)
Transgenic Mouse
(1)
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Showing Publications 1 - 10 of 215. Show All 215 Publications.
Publications using MJE00B Applications Species
de Souza, S;Rosario Claudio, J;Sim, J;Inyang, KE;Dagenais, A;Monahan, K;Lee, B;Ramakrishnan, H;Parmar, V;Geron, M;Scherrer, G;Folger, JK;Laumet, G; Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response Brain, behavior, and immunity 2023-12-09 [PMID: 38081433]
Xu, M;Shi, F;Gao, Y;Han, S;Huang, C;Hou, Q;Wen, X;Wang, B;Zhu, Z;Zou, L;Xiong, M;Dong, W;Tan, J; Arabinose confers protection against intestinal injury by improving integrity of intestinal mucosal barrier International immunopharmacology 2023-11-22 [PMID: 37995573] (Mouse) Mouse
Zhou, W;Yuan, W;Chen, Y;Li, C;Hu, L;Li, Q;Wang, J;Xue, R;Sun, Y;Xia, Q;Hu, L;Wei, Y;He, M; Single-cell transcriptomics reveals the pulmonary inflammation induced by inhalation of subway fine particles Journal of hazardous materials 2023-11-02 [PMID: 37951166] (Mouse) Mouse
Kang, Z;Lin, Y;Su, C;Li, S;Xie, W;Wu, X; Hsp70 ameliorates sleep deprivation-induced anxiety-like behavior and cognitive impairment in mice Brain research bulletin 2023-10-17 [PMID: 37858682] (Mouse) Mouse
Ni, J;Guo, T;Zhou, Y;Jiang, S;Zhang, L;Zhu, Z; STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury Journal of translational medicine 2023-09-04 [PMID: 37667317] (Mouse) Mouse
Schroer, AB;Ventura, PB;Sucharov, J;Misra, R;Chui, MKK;Bieri, G;Horowitz, AM;Smith, LK;Encabo, K;Tenggara, I;Couthouis, J;Gross, JD;Chan, JM;Luke, A;Villeda, SA; Platelet factors attenuate inflammation and rescue cognition in ageing Nature 2023-08-16 [PMID: 37587343] (Mouse) Mouse
Tawarayama, H;Umeki, K;Inoue-Yanagimachi, M;Takahashi, N;Hasegawa, H;Himori, N;Tsuda, S;Kunikata, H;Akaike, T;Nakazawa, T; Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells Scientific reports 2023-07-17 [PMID: 37460786] (Mouse) Mouse
Schwarz, MM;Ganaie, SS;Feng, A;Brown, G;Yangdon, T;White, JM;Hoehl, RM;McMillen, CM;Rush, RE;Connors, KA;Cui, X;Leung, DW;Egawa, T;Amarasinghe, GK;Hartman, AL; Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice Science advances 2023-07-14 [PMID: 37450601] (Mouse) Mouse
Liu, PY;Chen, CY;Lin, YL;Lin, CM;Tsai, WC;Tsai, YL;Lin, GJ;Chen, YG;Wang, SY;Sun, RN;Huang, YC;Chang, H;Chen, YC; RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury Cell death & disease 2023-06-21 [PMID: 37344492] (Mouse) Mouse
Shinde, P;Kiepas, A;Zhang, L;Sudhir, S;Konstantopoulos, K;Stamatos, NM; Polysialylation controls immune function of myeloid cells in murine model of pneumococcal pneumonia Cell reports 2023-06-19 [PMID: 37339052] (Mouse) Mouse
Show All 215 Publications.

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Bioinformatics

Gene Symbol CCL2