MMP-12 Antibody (701E4.03)

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using DDX0284P-100	Applications	Species
Chaudhuri R et al. Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. J Allergy Clin Immunol 2012-03-01 [PMID: 22305682]
Souissi IJ et al. Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages. Exp Cell Res 2008-11-01 [PMID: 18823978]
Demets IK et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 2006-03-01 [PMID: 16308335]

Array DDX0284P-100

• MMP-12 Antibodies
• MMP-12 ELISA Kits
• MMP-12 Kit
• MMP-12 Proteins and Enzymes