Mitofusin 1 Antibody (11E9-1H12) [Biotin]

When mitochondria are impaired by genetic mutations or viral insertions, they are selectively isolated and destroyed by complicated intracellular mechanisms. The mitochondrial fusion-promoting factor MFN1 is a critical contributor to mediating this selective process. MFN1 is ubiquinated by PINK1 after its recruitment by Parkin, and this post-translational modification is critical in catalyzing mitochondrial repair or removal by other cellular mechanisms. In both Parkinson's and Alzheimer's disease, as well as when viruses attempt to replicate, mitochondrial fission and mitophagy are erroneously regulated due to the mutation or elimination of MFN1. This disruption of mitochondrial repair and regulation is implicated in many of the phenotypic demonstrations of neurodegenerative disorders.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-71775B

• Mitofusin 1 Antibodies
• Mitofusin 1 Lysate
• Mitofusin 1 Proteins