MEK1 [p Thr292] Antibody

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation and this pathway also plays a key role in synaptic plasticity in brain. Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. Conversely there also appears to be a feedback phosphoylation of MEK 1 by MAP kinase. The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using NB500-145	Applications	Species
Park, SH, Zarrinpar, A Lim, WA. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299 1061 - 1064. 2003-01-01 [PMID: 12511654]
Adams, JP Sweatt, JD. Roles for the ERK MAP kinase cascade in memory, Annu. Rev Pharmacol Toxicol 42 135 - 163. 2002-01-01 [PMID: 11807168]
Ahn, NG, quot. The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol. Cell Biochem. 127 - 128 201 - 209. 1993-01-01 [PMID: 7935352]
Mansour, SJ, Resing, KA, Ci, JM, Hermann, AS, Gloor, JW, Herskind, KR, Wartmann, M, Davis, RJ, Ahn, NG, quot. Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry site-directed mutagenesis. J. Biochem. (Tokyo) 116 304. 1994-01-01 [PMID: 7822248]
Crews, CM, Alessrini, A, Erikson, RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258 478 - 480. 1992-01-01 [PMID: 1411546]
Ahn, NG, Robbins, DJ, Haycock, RW, Seger, R, Cobb, MH Krebs, EG, quot. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin, J. Neurochem 59 147 -156. 1992-01-01 [PMID: 1319464]

Images	Ratings	Applications	Species	Date	Details
Enlarge	3 reviewed by: Verified Customer	WB	Human	10/04/2015	View Summary Application Western Blot Sample Tested Human cancer cell whole cell lysate Species Human

Array NB500-145

• MEK1 Antibodies
• MEK1 ELISA Kits
• MEK1 Lysate
• MEK1 Proteins
• MEK1 Proteins and Enzyme