MEK1 Products

Description

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). This pathway also plays a key role in synaptic plasticity in brain (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992) Conversely there also appears to be a feedback phosphorylation of MEK 1 by MAP kinase. The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386 (Mansour et al., 1994).

Bioinformatics

Entrez	170851 Rat 26395 Mouse 5604 Human
Uniprot	NM_002755 Human NP_002746 Human NP_002746.1 Human P46734 Human Q02750 Human
Product By Gene ID	5604
Alternate Names	dual specificity mitogen-activated protein kinase kinase 1 ERK activator kinase 1 MAP kinase kinase 1 MAPK/ERK kinase 1 MAPKK1 MEK1MAPKK 1 mitogen-activated protein kinase kinase 1 MKK1MEK 1 PRKMK1EC 2.7.12.2 protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)

Research Areas for MEK1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Autophagy
Cancer
MAP Kinase Signaling
Phospho-Specific
Protein Phosphatase
Signal Transduction
Tyrosine Kinases