MeCP2 Antibody (4B6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using H00004204-M01	Applications	Species
Bueno C, Tabares-Seisdedos R, Moraleda JM, Martinez S Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands. PLoS One 2016-04-11 [PMID: 27064487]
Tai DJ, Liu YC, Hsu WL et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun 2016-02-04 [PMID: 26842955] (WB)	WB

Array H00004204-M01

• MeCP2 Antibodies
• MeCP2 ELISA Kits
• MeCP2 Lysate
• MeCP2 Proteins