FMRP Antibody (OTI1C6)

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq].

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP2-01770	Applications	Species
Yildirim Z, Baboo S, Hamid SM et al. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression EMBO molecular medicine 2022-02-22 [PMID: 35191199] (WB)	WB
Yang YM, Arsenault J, Bah A et al. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain. Mol. Psychiatry. 2018-09-17 [PMID: 30224722] (WB, Mouse)	WB	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	03/21/2018	View Summary Application Western Blot Sample Tested cerebellum lysate Species Mouse Lot A001 Comments Comments loaded 50ug total protein each lane. Anti-fmrp antibody used 1:1000. Washed 3 times in 0.1% PBST, 10 min each time.

Array NBP2-01770

• FMRP Antibodies
• FMRP ELISA Kits
• FMRP Lysate
• FMRP Proteins