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MAdCAM-1 Antibody (683715) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
683715
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB6056U-100UG
Alexa Fluor 405
FAB6056V-100UG
Alexa Fluor 488
FAB6056G-100UG
Alexa Fluor 532
FAB6056X
Alexa Fluor 594
FAB6056T-100UG
Alexa Fluor 647
FAB6056R-100UG
Alexa Fluor 700
FAB6056N-100UG
Alexa Fluor 750
FAB6056S-100UG
Allophycocyanin
FAB6056A
Allophycocyanin/Cy7
FAB6056APCCY7
Biotin
FAB6056B
CoraFluor 1
FAB6056CL1
DyLight 350
FAB6056D
DyLight 405
FAB6056E
DyLight 488
FAB6056K
DyLight 550
FAB6056L
DyLight 594
FAB6056M
DyLight 650
FAB6056W
DyLight 680
FAB6056Y
DyLight 755
FAB6056Z
FITC
FAB6056F
HRP
FAB6056H
Janelia Fluor 525
FAB6056JF525
Janelia Fluor 549
FAB6056I
Janelia Fluor 585
FAB6056JF585
Janelia Fluor 635
FAB6056JF635
Janelia Fluor 669
FAB6056JF669
PE
FAB6056P
PE/Atto594
FAB6056PEATT594
PE/Cy5.5
FAB6056PECY55
PE/Cy7
FAB6056PECY7
PerCP
FAB6056C
Unconjugated
MAB6056
mFluor Violet 450 SE
FAB6056MFV450
mFluor Violet 500 SE
FAB6056MFV500
mFluor Violet 610 SE
FAB6056MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB6056
Carrier Free
MAB6056
Carrier Free
FAB6056A
Carrier Free
MAB6056-SP
Carrier Free
FAB6056S-100UG
Carrier Free
FAB6056R-100UG
Carrier Free
FAB6056N-100UG
Carrier Free
FAB6056G-100UG
Carrier Free
FAB6056V-100UG
Carrier Free
FAB6056U-100UG
Carrier Free
FAB6056T-100UG
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MAdCAM-1 Antibody (683715) [Janelia Fluor® 646] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human MAdCAM-1
Leu21-Gln333
Accession # AAY82472
Specificity
Detects human MAdCAM-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse MAdCAM-1, recombinant human (rh) ALCAM, rhBCAM, rhCEACAM-1, rhEpCAM, rhICAM-1, -2, -3, -4, -5, rhCD31/PECAM-1, or rhVCAM-1 is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
MADCAM1
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MAdCAM-1 Antibody (683715) [Janelia Fluor® 646]

  • hMAdCAM-1
  • MACAM1
  • MAdCAM1
  • MAdCAM-1
  • mucosal addressin cell adhesion molecule 1
  • mucosal addressin cell adhesion molecule-1
  • mucosal vascular addressin cell adhesion molecule 1

Background

Mucosal vascular addressin-1 (MAdCAM-1) is a type I transmembrane glycoprotein expressed at high levels on high endothelial venules (HEV) of Peyer's patches and mesenteric lymph nodes, and on flat walled venules within the gut lamina propria. It is also expressed on sinus-lining cells in the spleen. (1-3) The countereceptor or "homing receptor" for MAdCAM-1 is alpha4beta7 integrin (also known as LPAM-1). MAdCAM-1 is also a facultative ligand for CD62L/L-selectin. (4, 5) The monoclonal antibody MECA-367 binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer's patch HEV in vivo. (1, 2, 4)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MADCAM1