Recombinant Mouse M-CSF Protein

This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.

Macrophage Colony Stimulating Factor (M-CSF), also named CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. It is produced by osteoblasts (as a result of endocrine stimulation by parathyroid hormone) exerts paracrine effects on osteoclasts and can interact with CSF1R. M-CSF is a four alpha-helical bundle cytokine and its active form is found extracellularly as a disulfide-linked homodimer. Four transcript variants encoding three different isoforms have been reported for M-CSF gene. Although forms may vary, all of them contain the N-terminal 150 a.a. portion that is necessary and sufficient for interaction with the receptor. The first 229 a.a. of mature mouse M-CSF shares 87 %, 83 %, 82 % and 81 % sequence identity with corresponding regions of rat, dog, cow and human M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: BA, Cell Culture.

Showing Publications 1 - 3 of 3.

Publications using NBP2-35165	Applications	Species
Huang L, Xu R, Li W et al. Repolarization of macrophages to improve sorafenib sensitivity for combination cancer therapy Acta biomaterialia 2023-03-16 [PMID: 36931417] (BA, Mouse)	BA	Mouse
Cao S, Saw PE, Shen Q Et al. Reduction-responsive RNAi nanoplatform to reprogram tumor lipid metabolism and repolarize macrophage for combination pancreatic cancer therapy Biomaterials 2021-11-19 [PMID: 34823884] (Cell Culture)	Cell Culture
Li Y, Dong M, Wang Q et al. HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype Basic research in cardiology 2021-04-23 [PMID: 33893593] (Mouse)		Mouse

Array NBP2-35165

• M-CSF Antibodies
• M-CSF Antibody Pair
• M-CSF ELISA Kits
• M-CSF Lysates
• M-CSF Proteins
• M-CSF ELISAs
• M-CSF Proteins and Enzymes