M-CSF Antibody (26730) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

M-CSF, also known as CSF-1, is a four-alpha-helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen. Shorter transcripts encode M-CSF that lack cleavage and PG sites and produce an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer. Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Cell Culture, Neutralization.

Showing Publications 1 - 3 of 3.

Publications using MAB216	Applications	Species
Yamei Zhou, Jia Zeng, Yuanyuan Tu, Lele Li, Shu Du, Linling Zhu et al. CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization Investigative Opthalmology & Visual Science 3/25/2021 [PMID: 33764399]
RM Rodriguez, B Suarez-Alv, JL Lavín, AM Ascensión, M Gonzalez, JJ Lozano, AB Raneros, PD Bulnes, JR Vidal-Cast, C Huidobro, C Martin-Mar, AB Sanz, M Ruiz-Orteg, A Puig-Kröge, AL Corbí, MJ Araúzo-Bra, AM Aransay, C Lopez-Larr Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes Cell Rep, 2019-10-22;29(4):860-872.e5. 2019-10-22 [PMID: 31644909] (Cell Culture, Human)	Cell Culture	Human
Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood, 2007-09-11;110(13):4319-30. 2007-09-11 [PMID: 17848619] (Neutralization, Human)	Neutralization	Human

Array MAB216

• M-CSF Antibodies
• M-CSF Antibody Pair
• M-CSF ELISA Kits
• M-CSF Lysates
• M-CSF Proteins
• M-CSF Proteins and Enzymes
• M-CSF ELISAs