Lipocalin-2/NGAL Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse Lipocalin-2 was cloned from mouse kidney cells (1). Its very high level of expression at the post-stratum uterus gave it the name uterocalin (2). Lipocalin-2 has been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis (3- 5). Studies indicate that Lipocalin-2 binds a bacterial catecholate siderophore that is bound to a ferric ion, such as enterobactin, with a subnanomolar dissociation constant (K_d = 0.41 nM) (6). The bound ferric enterobactin complex breaks down slowly in a month into dihydroxybenzoyl serine and dihydroxybenzoic acid (DHBA). It also binds to a ferric DHBA complex with much less K_d values (7.9 nM) (6). Secretion of Lipocalin-2 in immune cells increases in response to stimulation of Toll-like receptor as an acute phase response to infection. As a result, it acts as a potent bacteriostatic reagent by sequestering iron (7). Moreover, Lipocalin-2 can alter the invasive and metastatic behavior of Ras-transformed breast cancer cells in vitro and in vivo by reversing the epithelial to mesenchymal transition inducing activity of Ras, through restoration of E-cadherin expression, via effects on the Ras-MAPK signaling pathway (8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 11 applications: Bioassay, ELISA Development, ICC, IHC, IHC-Fr, IHC-P, IHC/IF, IP, Immunohistochemistry, Neutralization, Western Blot.

Showing Publications 1 - 10 of 107. Show All 107 Publications. Collapse Publications.

Publications using AF1857	Applications	Species
Vlasschaert, C;Robinson-Cohen, C;Chen, J;Akwo, E;Parker, AC;Silver, SA;Bhatraju, PK;Poisner, H;Cao, S;Jiang, M;Wang, Y;Niu, A;Siew, E;Van Amburg, JC;Kramer, HJ;Kottgen, A;Franceschini, N;Psaty, BM;Tracy, RP;Alonso, A;Arking, DE;Coresh, J;Ballantyne, CM;Boerwinkle, E;Grams, M;Zhang, MZ;Kestenbaum, B;Lanktree, MB;Rauh, MJ;Harris, RC;Bick, AG; Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury Nature medicine 2024-03-01 [PMID: 38454125] (Western Blot, Mouse)	Western Blot	Mouse
Lee, J;An, HS;Shin, HJ;Jang, HM;Im, CO;Jeong, Y;Eum, K;Yoon, S;Lee, SJ;Jeong, EA;Kim, KE;Roh, GS; Intermittent Fasting Reduces Neuroinflammation and Cognitive Impairment in High-Fat Diet-Fed Mice by Downregulating Lipocalin-2 and Galectin-3 Nutrients 2024-01-03 [PMID: 38201988] (Immunohistochemistry, Western Blot, Mouse)	Immunohistochemistry, Western Blot	Mouse
Su, H;Guo, H;Qiu, X;Lin, TY;Qin, C;Celio, G;Yong, P;Senders, M;Han, X;Bernlohr, DA;Chen, X; Lipocalin 2 regulates mitochondrial phospholipidome remodeling, dynamics, and function in brown adipose tissue in male mice Nature communications 2023-10-23 [PMID: 37872178] (Bioassay, ICC, Western Blot, Mouse)	Bioassay, ICC, Western Blot	Mouse
Beltran-Lobo, P;Hughes, MM;Troakes, C;Croft, CL;Rupawala, H;Jutzi, D;Ruepp, MD;Jimenez-Sanchez, M;Perkinton, MS;Kassiou, M;Golde, TE;Hanger, DP;Verkhratsky, A;Perez-Nievas, BG;Noble, W; P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes Brain, behavior, and immunity 2023-09-15 [PMID: 37716378] (Western Blot, Mouse)	Western Blot	Mouse
Marques, E;Alves Teixeira, M;Nguyen, C;Terzi, F;Gallazzini, M; Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation Cell reports 2023-08-24 [PMID: 37624695] (Western Blot, ICC, Mouse)	Western Blot, ICC	Mouse
Deng, Z;Wang, Y;Liu, J;Zhang, H;Zhou, L;Zhao, H;Han, Y;Yan, S;Dong, Z;Wang, Y;Dai, Y;Deng, F; WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury Redox biology 2023-07-26 [PMID: 37516014] (Western Blot, Mouse)	Western Blot	Mouse
Patel, S;Sparman, NZR;Arneson, D;Alvarsson, A;Santos, LC;Duesman, SJ;Centonze, A;Hathaway, E;Ahn, IS;Diamante, G;Cely, I;Cho, CH;Talari, NK;Rajbhandari, AK;Goedeke, L;Wang, P;Butte, AJ;Blanpain, C;Chella Krishnan, K;Lusis, AJ;Stanley, SA;Yang, X;Rajbhandari, P; Mammary duct luminal epithelium controls adipocyte thermogenic programme Nature 2023-07-26 [PMID: 37495690] (IHC/IF, Mouse)	IHC/IF	Mouse
Berquez, M;Chen, Z;Festa, BP;Krohn, P;Keller, SA;Parolo, S;Korzinkin, M;Gaponova, A;Laczko, E;Domenici, E;Devuyst, O;Luciani, A; Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization Nature communications 2023-07-14 [PMID: 37452023] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
Pepino, L;Malapert, P;Saurin, AJ;Moqrich, A;Reynders, A; Formalin-evoked pain triggers sex-specific behavior and spinal immune response Scientific reports 2023-06-12 [PMID: 37308519] (IHC, ICC, Mouse)	IHC, ICC	Mouse
Vlasschaert, C;Robinson-Cohen, C;Kestenbaum, B;Silver, SA;Chen, JC;Akwo, E;Bhatraju, PK;Zhang, MZ;Cao, S;Jiang, M;Wang, Y;Niu, A;Siew, E;Kramer, HJ;Kottgen, A;Franceschini, N;Psaty, BM;Tracy, RP;Alonso, A;Arking, DE;Coresh, J;Ballantyne, CM;Boerwinkle, E;Grams, M;Lanktree, MB;Rauh, MJ;Harris, RC;Bick, AG; Clonal Hematopoiesis of Indeterminate Potential is Associated with Acute Kidney Injury medRxiv : the preprint server for health sciences 2023-05-17 [PMID: 37292692] (Western Blot, Mouse)	Western Blot	Mouse
Shohei Tanaka, Hiromichi Wakui, Kengo Azushima, Shunichiro Tsukamoto, Takahiro Yamaji, Shingo Urate et al. Effects of a High-Protein Diet on Kidney Injury under Conditions of Non-CKD or CKD in Mice International Journal of Molecular Sciences 4/24/2023 [PMID: 37175483]
Liu, Y;Smith, MR;Wang, Y;D'Agostino, R;Ruiz, J;Lycan, T;Kucera, GL;Miller, LD;Li, W;Chan, MD;Farris, M;Su, J;Song, Q;Zhao, D;Chandrasekaran, A;Xing, F; c-Met Mediated Cytokine Network Promotes Brain Metastasis of Breast Cancer by Remodeling Neutrophil Activities Cancers 2023-05-05 [PMID: 37174093]
Dong Wang, Xiaohui Li, Defeng Jiao, Ying Cai, Liting Qian, Yiqing Shen et al. LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia Journal of Hematology & Oncology 3/27/2023 [PMID: 36973755]
I Nagayama, K Takayanagi, H Hasegawa, A Maeshima Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage Cells, 2023-03-04;12(5):. 3/4/2023 [PMID: 36899937]
Tingfang Mei, Jinwen Wu, Keling Wu, Minglei Zhao, Jingyi Luo, Xinqi Liu et al. Lipocalin 2 induces visual impairment by promoting ferroptosis in retinal ischemia-reperfusion injury Annals of Translational Medicine 1/15/2023 [PMID: 36760251]
R Greite, J Störmer, F Gueler, R Khalikov, A Haverich, C Kühn, N Madrahimov, R Natanov Different Acute Kidney Injury Patterns after Renal Ischemia Reperfusion Injury and Extracorporeal Membrane Oxygenation in Mice International Journal of Molecular Sciences, 2022-09-20;23(19):. 2022-09-20 [PMID: 36232304] (IHC, Mouse)	IHC	Mouse
O'Shea TM, Ao Y, Wang S et al. Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice Nature Communications 2022-09-28 [PMID: 36171203]
O'Shea TM, Ao Y, Wang S et al. Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice Nature Communications 9/28/2022 [PMID: 36171203]
Kayla R. McCullough, Juheb Akhter, Mauhaun J. Taheri, Amie Traylor, Anna A. Zmijewska, Vivek Verma et al. Functional consequence of myeloid ferritin heavy chain on acute and chronic effects of rhabdomyolysis-induced kidney injury Frontiers in Medicine 9/8/2022 [PMID: 36160140]
C Zhang, Y Guan, J Zou, X Yang, G Bayliss, S Zhuang Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury Cell Death & Disease, 2022-09-06;13(9):770. 2022-09-06 [PMID: 36068197] (IHC, Mouse)	IHC	Mouse
JR Sheldon, LE Himmel, DE Kunkle, AJ Monteith, KN Maloney, EP Skaar Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection PloS Pathogens, 2022-09-02;18(9):e1010809. 2022-09-02 [PMID: 36054235] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis Does G Protein-Coupled Estrogen Receptor 1 Contribute to Cisplatin-Induced Acute Kidney Injury in Male Mice? International Journal of Molecular Sciences 7/27/2022 [PMID: 35955435]
M Silva Oliv, J Schira-Hei, L Reiche, S Han, VCM de Amorim, I Lewen, J Gruchot, P Göttle, R Akkermann, K Azim, P Küry Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations EBioMedicine, 2022-08-08;83(0):104204. 2022-08-08 [PMID: 35952494] (IHC, Mouse)	IHC	Mouse
HJ Shin, Z Jin, HS An, G Park, JY Lee, SJ Lee, HM Jang, EA Jeong, KE Kim, J Lee, DY Yoo, GS Roh Lipocalin-2 Deficiency Reduces Hepatic and Hippocampal Triggering Receptor Expressed on Myeloid Cells-2 Expressions in High-Fat Diet/Streptozotocin-Induced Diabetic Mice Brain sciences, 2022-07-02;12(7):. 2022-07-02 [PMID: 35884685] (Western Blot, Mouse)	Western Blot	Mouse
Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R Molenaar, Luigi R De La Motte et al. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes eLife 5/12/2022 [PMID: 35550039]
X Xiang, X Tang, Y Yu, S Xie, L Liu, M Chen, R Zhang, X Kang, Y Zheng, G Yang, S Gan, S Zhu Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia Journal of Neuroinflammation, 2022-04-12;19(1):92. 2022-04-12 [PMID: 35413913] (IHC, Mouse)	IHC	Mouse
T Eckes, S Patyna, A Koch, A Oftring, S Gauer, N Obermüller, S Schwalm, L Schaefer, J Chun, HJ Gröne, J Pfeilschif Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy International Journal of Molecular Sciences, 2022-04-02;23(7):. 2022-04-02 [PMID: 35409312] (Western Blot, Mouse)	Western Blot	Mouse
T Wan, W Zhu, Y Zhao, X Zhang, R Ye, M Zuo, P Xu, Z Huang, C Zhang, Y Xie, X Liu Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice Nature Communications, 2022-03-03;13(1):1134. 2022-03-03 [PMID: 35241660] (ICC, Mouse)	ICC	Mouse
TH Shen, J Stauber, K Xu, A Jacunski, N Paragas, M Callahan, R Banlengchi, AD Levitman, B Desanti de, A Beenken, MS Grau, E Mathieu, Q Zhang, Y Li, T Gopal, N Askanase, S Arumugam, S Mohan, PI Good, JS Stevens, F Lin, SK Sia, CS Lin, V D'Agati, K Kiryluk, NP Tatonetti, J Barasch Snapshots of nascent RNA reveal cell- and stimulus- specific responses to acute kidney injury JCI Insight, 2022-03-22;0(0):. 2022-03-22 [PMID: 35230973] (Western Blot, Mouse)	Western Blot	Mouse
Patrick Krohn, Laura Rita Rega, Marianne Harvent, Beatrice Paola Festa, Anna Taranta, Alessandro Luciani et al. Multisystem involvement, defective lysosomes and impaired autophagy in a novel rat model of nephropathic cystinosis Human Molecular Genetics 7/7/2022 [PMID: 35137071]
Kensuke Sasaki, Andrew S. Terker, Jiaqi Tang, Shirong Cao, Juan Pablo Arroyo, Aolei Niu et al. Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis JCI Insight 2/22/2022 [PMID: 35025763]
N Helmrich, M Roderfeld, A Baier, A Windhorst, D Herebian, E Mayatepek, C Dierkes, M Ocker, D Glebe, B Christ, Y Churin, K Irungbam, E Roeb Pharmacological Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4-/- Mice Cellular and Molecular Gastroenterology and Hepatology, 2021-12-23;0(0):. 2021-12-23 [PMID: 34954190] (Western Blot, Mouse)	Western Blot	Mouse
F Yao, Y Deng, Y Zhao, Y Mei, Y Zhang, X Liu, C Martinez, X Su, RR Rosato, H Teng, Q Hang, S Yap, D Chen, Y Wang, MM Chen, M Zhang, H Liang, D Xie, X Chen, H Zhu, JC Chang, MJ You, Y Sun, B Gan, L Ma A targetable LIFR-NF-kappaB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis Nature Communications, 2021-12-17;12(1):7333. 2021-12-17 [PMID: 34921145] (IHC, Mouse)	IHC	Mouse
Majumder S, Pushpakumar S, Juin SK et al. Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury Pharmacological research 12/9/2021 [PMID: 34896544]
N Ma, Z Wei, J Hu, W Gu, X Ci Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway Frontiers in Pharmacology, 2021-11-11;12(0):768700. 2021-11-11 [PMID: 34858188] (Western Blot, Mouse, Transgenic Mouse)	Western Blot	Mouse, Transgenic Mouse
S Talley, R Valiauga, L Anderson, AR Cannon, MA Choudhry, EM Campbell DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod Journal of Neuroinflammation, 2021-11-10;18(1):263. 2021-11-10 [PMID: 34758843] (Western Blot, Mouse)	Western Blot	Mouse
Cheng Z, Akatsuka S, Li GH et al. Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis Cancer Science 1/1/2022 [PMID: 34699654]
Cheng Z, Akatsuka S, Li GH et al. Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis Cancer Science 2022-01-01 [PMID: 34699654]
H Ahn, G Lee, J Kim, J Park, SG Kang, SI Yoon, E Lee, GS Lee NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation Cells, 2021-07-02;10(7):. 2021-07-02 [PMID: 34359830] (Western Blot, Mouse)	Western Blot	Mouse
John F. Brooks, Cassie L. Behrendt, Kelly A. Ruhn, Syann Lee, Prithvi Raj, Joseph S. Takahashi et al. The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock Cell 8/1/2021 [PMID: 34324837]
Zhao S, Wang X, Zheng X Et Al. Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage Free radical biology & medicine 7/21/2021 [PMID: 34298093]
B Olson, X Zhu, MA Norgard, P Diba, PR Levasseur, AC Buenafe, C Huisman, KG Burfeind, KA Michaelis, G Kong, T Braun, DL Marks Chronic cerebral lipocalin 2 exposure elicits hippocampal neuronal dysfunction and cognitive impairment Brain, Behavior, and Immunity, 2021-07-08;0(0):. 2021-07-08 [PMID: 34245812] (IHC, Mouse)	IHC	Mouse
Azusa Yoneshige, Man Hagiyama, Yasutoshi Takashima, Satoru Ueno, Takao Inoue, Ryuichiro Kimura et al. Elevated Hydrostatic Pressure Causes Retinal Degeneration Through Upregulating Lipocalin-2 Frontiers in Cell and Developmental Biology 5/31/2021 [PMID: 34136483]
B Olson, X Zhu, MA Norgard, PR Levasseur, JT Butler, A Buenafe, KG Burfeind, KA Michaelis, KR Pelz, H Mendez, J Edwards, SM Krasnow, AJ Grossberg, DL Marks Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia Nature Communications, 2021-04-06;12(1):2057. 2021-04-06 [PMID: 33824339] (IHC, Mouse)	IHC	Mouse
Gregory J. Heller, Michael S. Marshall, Yazan Issa, Jeffrey N. Marshall, Duc Nguyen, Emily Rue et al. Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease Molecular Therapy 5/1/2021 [PMID: 33508430]
E Staurenghi, V Cerrato, P Gamba, G Testa, S Giannelli, V Leoni, C Caccia, A Buffo, W Noble, BG Perez-Niev, G Leonarduzz Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2 Redox Biology, 2020-12-17;39(0):101837. 2020-12-17 [PMID: 33360775] (Western Blot, Mouse)	Western Blot	Mouse
Nicolas S. Merle, Juliette Leon, Victoria Poillerat, Anne Grunenwald, Idris Boudhabhay, Samantha Knockaert et al. Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis Frontiers in Immunology 8/7/2020 [PMID: 32849636]
Erawan Borkham-Kamphorst, Ute Haas, Eddy Van de Leur, Anothai Trevanich, Ralf Weiskirchen Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice through Endoplasmic Reticulum Stress and Unfolded Protein Response International Journal of Molecular Sciences 7/23/2020 [PMID: 32718038]
A Mondal, D Bose, P Saha, S Sarkar, R Seth, D Kimono, M Albadrani, M Nagarkatti, P Nagarkatti, S Chatterjee Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis J Neuroinflammation, 2020-07-04;17(1):201. 2020-07-04 [PMID: 32622362] (IHC, Mouse)	IHC	Mouse
Xu, C, Wang, L Et al. Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms. J Am Soc Nephrol 5/1/2020 [PMID: 32253273]
Y-F Liu, M-Y Li, Y-P Yan, W Wei, B Li, H-Y Pan et al. ER alpha -dependent stimulation of LCN2 in uterine epithelium during mouse early pregnancy Reproduction 4/1/2020 [PMID: 31967970]
EM Buhl, S Djudjaj, BM Klinkhamme, K Ermert, VG Puelles, MT Lindenmeye, CD Cohen, C He, E Borkham-Ka, R Weiskirche, B Denecke, P Trairatphi, J Saez-Rodri, TB Huber, LE Olson, J Floege, P Boor Dysregulated mesenchymal PDGFR-&beta drives kidney fibrosis EMBO Mol Med, 2020-01-14;0(0):e11021. 2020-01-14 [PMID: 31943786] (IHC, Mouse)	IHC	Mouse
Heather L. Smith, Oliver J. Freeman, Adrian J. Butcher, Staffan Holmqvist, Ibrahim Humoud, Tobias Schätzl et al. Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration Neuron 3/4/2020 [PMID: 31924446]
K Chella Kri, S Sabir, M Shum, Y Meng, R Acín-Pérez, JM Lang, RR Floyd, L Vergnes, MM Seldin, BK Fuqua, DW Jayasekera, SK Nand, DC Anum, C Pan, L Stiles, M Péterfy, K Reue, M Liesa, AJ Lusis Sex-specific metabolic functions of adipose Lipocalin-2 Mol Metab, 2019-09-27;30(0):30-47. 2019-09-27 [PMID: 31767179] (Western Blot, Mouse)	Western Blot	Mouse
L Yammine, A Zablocki, W Baron, F Terzi, M Gallazzini Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking Cell Rep, 2019-11-12;29(7):2067-2077.e6. 2019-11-12 [PMID: 31722218] (IP, Human)	IP	Human
X Feng, D Guan, T Auen, JW Choi, MA Salazar-He, F Faruk, KD Copps, U Ozcan Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight Sci Rep, 2019-09-05;9(1):12809. 9/5/2019 [PMID: 31488870]
Yanyong Xu, Yingdong Zhu, Kavita Jadhav, Yuanyuan Li, Huihui Sun, Liya Yin et al. Lipocalin‐2 Protects Against Diet‐Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes Hepatology Communications 6/1/2019 [PMID: 31168511]
KJ Meade, F Sanchez, A Aguayo, N Nadales, SG Hamalian, TL Uhlendorf, LR Banner, JA Kelber Secretomes from metastatic breast cancer cells, enriched for a prognostically unfavorable LCN2 axis, induce anti-inflammatory MSC actions and a tumor-supportive premetastatic lung Oncotarget, 2019-04-30;10(32):3027-3039. 2019-04-30 [PMID: 31105883] (Western Blot, Mouse)	Western Blot	Mouse
K Noh, H Lee, TY Choi, Y Joo, SJ Kim, H Kim, JY Kim, JW Jahng, S Lee, SY Choi, SJ Lee Negr1 controls adult hippocampal neurogenesis and affective behaviors Mol. Psychiatry, 2019-01-16;0(0):. 2019-01-16 [PMID: 30651602] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Arif A, Jia J, Willard B et al. Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection. Mol. Cell 12/27/2018 [PMID: 30612880]
TA Yakulov, AP Todkar, K Slanchev, J Wiegel, A Bona, M Gro beta , A Scholz, I Hess, A Wurditsch, F Grahammer, TB Huber, V Lecaudey, T Bork, J Hochrein, M Boerries, J Leenders, P de Tullio, F Jouret, A Kramer-Zuc, G Walz CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury Nat Commun, 2018-09-10;9(1):3660. 2018-09-10 [PMID: 30202007] (Western Blot, Mouse)	Western Blot	Mouse
F Pacifico, L Pisa, S Mellone, M Cillo, A Lepore, A Leonardi NGAL promotes recruitment of tumor infiltrating leukocytes Oncotarget, 2018-07-20;9(56):30761-30772. 7/20/2018 [PMID: 30112105]
Zhong‑Min Han, He‑Mei Huang, Yong‑Wu Sun Effect of CEACAM‑1 knockdown in human colorectal cancer cells Oncology Letters 5/30/2018 [PMID: 30008845]
H Langhorst, R Jüttner, D Groneberg, A Mohtashamd, L Pelz, B Purfürst, KM Schmidt-Ot, A Friebe, FG Rathjen The IgCAM CLMP is required for intestinal and ureteral smooth muscle contraction by regulating Connexin43 and 45 expression in mice Dis Model Mech, 2018-02-22;0(0):. 2018-02-22 [PMID: 29361518] (Western Blot, Mouse)	Western Blot	Mouse
S Ueno, A Yoneshige, Y Koriyama, M Hagiyama, Y Shimomura, A Ito Early Gene Expression Profile in Retinal Ganglion Cell Layer After Optic Nerve Crush in Mice Invest. Ophthalmol. Vis. Sci., 2018-01-01;59(1):370-380. 2018-01-01 [PMID: 29346801] (Western Blot, Mouse)	Western Blot	Mouse
Lin-Li Lv, Ye Feng, Yi Wen, Wei-Jun Wu, Hai-Feng Ni, Zuo-Lin Li et al. Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation Journal of the American Society of Nephrology 3/1/2018 [PMID: 29295871]
Y Kim, SJ Park, SR Manson, CA Molina, K Kidd, H Thiessen-P, RJ Perry, H Liapis, S Kmoch, CR Parikh, AJ Bleyer, YM Chen Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease JCI Insight, 2017-12-07;2(23):. 2017-12-07 [PMID: 29212948] (Western Blot, Mouse)	Western Blot	Mouse
Melanie Mettang, Stephanie Nadine Reichel, Michael Lattke, Annette Palmer, Alireza Abaei, Volker Rasche et al. IKK2/NF‐ kappa B signaling protects neurons after traumatic brain injury The FASEB Journal 4/1/2018 [PMID: 29187362]
M Trudu, C Schaeffer, M Riba, M Ikehata, P Brambilla, P Messa, F Martinelli, MP Rastaldi, L Rampoldi Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations Sci Rep, 2017-08-07;7(1):7383. 2017-08-07 [PMID: 28785050] (Western Blot, Mouse)	Western Blot	Mouse
Ravindra Boddu, Chunlan Fan, Sunil Rangarajan, Bhuvana Sunil, Subhashini Bolisetty, Lisa M. Curtis Unique sex- and age-dependent effects in protective pathways in acute kidney injury American Journal of Physiology-Renal Physiology 9/1/2017 [PMID: 28679590]
Amy T Ku, Timothy M Shaver, Ajay S Rao, Jeffrey M Howard, Christine N Rodriguez, Qi Miao et al. TCF7L1 promotes skin tumorigenesis independently of beta -catenin through induction of LCN2 eLife 5/3/2017 [PMID: 28467300]
A Eskilsson, T Matsuwaki, K Shionoya, E Mirrasekhi, J Zajdel, M Schwaninge, D Engblom, A Blomqvist Immune-induced fever is dependent on local but not generalized prostaglandin E2 synthesis in the brain J. Neurosci., 2017-04-24;0(0):. 2017-04-24 [PMID: 28438967] (IHC, Mouse)	IHC	Mouse
I Mosialou, S Shikhel, JM Liu, A Maurizi, N Luo, Z He, Y Huang, H Zong, RA Friedman, J Barasch, P Lanzano, L Deng, RL Leibel, M Rubin, T Nicholas, W Chung, LM Zeltser, KW Williams, JE Pessin, S Kousteni MC4R-dependent suppression of appetite by bone-derived lipocalin 2 Nature, 2017-03-08;543(7645):385-390. 2017-03-08 [PMID: 28273060] (Western Blot, Mouse)	Western Blot	Mouse
Cyclooxygenase Isoform Exchange Blocks Brain-Mediated Inflammatory Symptoms PLoS ONE, 2016-11-18;11(11):e0166153. 2016-11-18 [PMID: 27861574] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Keap1 hypomorphism protects against ischemic and obstructive kidney disease Sci Rep, 2016-11-02;6(0):36185. 2016-11-02 [PMID: 27804998] (Western Blot, Mouse)	Western Blot	Mouse
Beneficial Effects of Sodium Phenylbutyrate Administration During Infection with Salmonella enterica serovar Typhimurium Infect Immun, 2016-08-19;0(0):. 2016-08-19 [PMID: 27382022] (Western Blot, Mouse)	Western Blot	Mouse
Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons PLoS Pathog, 2016-05-05;12(5):e1005572. 2016-05-05 [PMID: 27149619] (Western Blot, Mouse)	Western Blot	Mouse
GJ Song, M Jung, JH Kim, H Park, MH Rahman, S Zhang, ZY Zhang, DH Park, H Kook, IK Lee, K Suk A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation J Neuroinflammation, 2016-04-19;13(1):86. 2016-04-19 [PMID: 27095436] (Western Blot, Mouse)	Western Blot	Mouse
Khalil El Karoui, Amandine Viau, Olivier Dellis, Alessia Bagattin, Clément Nguyen, William Baron et al. Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2 Nature Communications 1/20/2016 [PMID: 26787103]
Weng Y, Wang G, Messing R, Chou W Identification of lipocalin-2 as a PKCdelta phosphorylation substrate in neutrophils. J Biomed Sci, 2015-03-20;22(0):21. 2015-03-20 [PMID: 25890235] (ICC, Western Blot, Mouse)	ICC, Western Blot	Mouse
Drew B, Hamidi H, Zhou Z, Villanueva C, Krum S, Calkin A, Parks B, Ribas V, Kalajian N, Phun J, Daraei P, Christofk H, Hewitt S, Korach K, Tontonoz P, Lusis A, Slamon D, Hurvitz S, Hevener A Estrogen receptor (ER)alpha-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem, 2014-12-02;290(9):5566-81. 2014-12-02 [PMID: 25468909] (Western Blot, Mouse)	Western Blot	Mouse
Wouter N. Leonhard, Malu Zandbergen, Kimberley Veraar, Susan van den Berg, Louise van der Weerd, Martijn Breuning et al. Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease Journal of the American Society of Nephrology 6/1/2015 [PMID: 25361818]
Lan Chen, Lajos Markó, Mario Ka beta mann, Ye Zhu, Kaiyin Wu, Maik Gollasch Role of TRPV1 Channels in Ischemia/Reperfusion-Induced Acute Kidney Injury PLoS ONE 10/17/2014 [PMID: 25330307]
Guo H, Jin D, Chen X Lipocalin 2 is a regulator of macrophage polarization and NF-kappaB/STAT3 pathway activation. Mol Endocrinol, 2014-08-15;28(10):1616-28. 2014-08-15 [PMID: 25127375] (Western Blot, Mouse)	Western Blot	Mouse
Rucci N, Capulli M, Piperni S, Cappariello A, Lau P, Frings-Meuthen P, Heer M, Teti A Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis. J Bone Miner Res, 2015-02-01;30(2):357-68. 2015-02-01 [PMID: 25112732] (Bioassay, Mouse)	Bioassay	Mouse
Grahammer F, Haenisch N, Steinhardt F, Sander L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg M, Hall M, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber T mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci U S A, 2014-06-23;111(27):E2817-26. 2014-06-23 [PMID: 24958889] (Western Blot, Mouse)	Western Blot	Mouse
Paragas N, Kulkarni R, Werth M, Schmidt-Ott K, Forster C, Deng R, Zhang Q, Singer E, Klose A, Shen T, Francis K, Ray S, Vijayakumar S, Seward S, Bovino M, Xu K, Takabe Y, Amaral F, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin C, Qiu A, Al-Awqati Q, Ratner A, Barasch J alpha-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest, 2014-06-17;124(7):2963-76. 2014-06-17 [PMID: 24937428] (Western Blot, Mouse)	Western Blot	Mouse
Zhang Y, Guo H, Deis J, Mashek M, Zhao M, Ariyakumar D, Armien A, Bernlohr D, Mashek D, Chen X Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism. J Biol Chem, 2014-06-10;289(32):22063-77. 2014-06-10 [PMID: 24917675] (Western Blot, Mouse)	Western Blot	Mouse
Miao Q, Ku A, Nishino Y, Howard J, Rao A, Shaver T, Garcia G, Le D, Karlin K, Westbrook T, Poli V, Nguyen H Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nat Commun, 2014-06-09;5(0):4088. 2014-06-09 [PMID: 24909826] (IHC, Neutralization, Mouse)	IHC, Neutralization	Mouse
Glenthoj A, Dahl S, Larsen M, Cowland J, Borregaard N Human alpha-defensin expression is not dependent on CCAAT/enhancer binding protein-epsilon in a murine model. PLoS ONE, 2014-03-21;9(3):e92471. 2014-03-21 [PMID: 24658030] (Western Blot, Mouse)	Western Blot	Mouse
Behnsen J, Jellbauer S, Wong C, Edwards R, George M, Ouyang W, Raffatellu M The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria. Immunity, 2014-02-06;40(2):262-73. 2014-02-06 [PMID: 24508234] (Western Blot, Mouse)	Western Blot	Mouse
Trudu M, Janas S, Lanzani C et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med. 12/1/2013 [PMID: 24185693]
Nocon A, Ip J, Terry R, Lim S, Getts D, Muller M, Hofer M, King N, Campbell I The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. J Virol, 2013-10-30;88(1):679-89. 2013-10-30 [PMID: 24173226] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
Tasso , Roberta, Ulivi , Valentin, Reverberi , Daniele, Lo Sicco , Claudia, Descalzi , Fiorella, Cancedda , Ranieri In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche. Stem Cells Dev, 2013-09-14;22(24):3178-91. 2013-09-14 [PMID: 23924051] (Western Blot, Mouse)	Western Blot	Mouse
Toshihisa Semba, Motoi Nishimura, Satomi Nishimura, Osamu Ohara, Takayuki Ishige, Sayaka Ohno et al. The FLS (Fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis BMC Gastroenterology 12/1/2013 [PMID: 23875831]
Jeon , Sangmin, Jha , Mithiles, Ock , Jiyeon, Seo , Jungwan, Jin , Myungwon, Cho , Heejung, Lee , Won-Ha, Suk , Kyoungho Role of lipocalin-2-chemokine axis in the development of neuropathic pain following peripheral nerve injury. J Biol Chem, 2013-07-08;288(33):24116-27. 2013-07-08 [PMID: 23836894] (IHC, Mouse)	IHC	Mouse
Corinne Cayatte, Barbara Joyce-Shaikh, Felix Vega, Katia Boniface, Jeffrey Grein, Erin Murphy et al. Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease Clinical and Translational Gastroenterology 2/16/2012 [PMID: 23238132]
Louten J, Mattson JD, Malinao MC, Li Y, Emson C, Vega F, Wardle RL, Van Scott MR, Fick RB, McClanahan TK, de Waal Malefyt R, Beaumont M Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma. Biomark Insights, 2012-07-10;7(0):87-104. 2012-07-10 [PMID: 22837640] (Western Blot, Mouse)	Western Blot	Mouse
Cramer EP, Glenthoj A, Hager M, Juncker-Jensen A, Engelholm LH, Santoni-Rugiu E, Lund LR, Laerum OD, Cowland JB, Borregaard N No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer. PLoS ONE, 2012-06-21;7(6):e39646. 2012-06-21 [PMID: 22737251] (ELISA Development, IHC-P, Western Blot, Mouse)	ELISA Development, IHC-P, Western Blot	Mouse
Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ, Zhou Y, Shinton SA, Hardy RR, Bezman NA, Sun JC, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Malhotra D, Turley SJ, Narayan K, Sylvia K, Kang J, Gazit R, Garrison B, Rossi DJ, Jojic V, Koller D, Jianu R, Laidlaw D, Costello J, Collins J, Cohen N, Brennan P, Brenner MB, Shay T, Regev A, Francis Kim TN, Rao A, Wagers EL, Gautier C, Jakubzick GJ, Randolph P, Monach AJ, Best J, Knell A, Goldrath T, Heng T, Kreslavsky M, Painter D, Mathis C, Benoist Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat. Immunol., 2012-04-01;13(5):499-510. 2012-04-01 [PMID: 22466668] (ICC, Mouse)	ICC	Mouse
Ip JP, Nocon AL, Hofer MJ, Lim SL, Muller M, Campbell IL Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. J Neuroinflammation, 2011-09-26;8(0):124. 2011-09-26 [PMID: 21943033] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
Mahadevan NR, Rodvold J, Almanza G, Perez AF, Wheeler MC, Zanetti M ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-kappaB-dependent manner. BMC Cancer, 2011-06-07;11(0):229. 2011-06-07 [PMID: 21649922] (Western Blot, Mouse)	Western Blot	Mouse
Hong Wu, Eric Santoni-Rugiu, Elisabeth Ralfkiaer, Bo T Porse, Claus Moser, Niels Høiby et al. Lipocalin 2 is protective against E. coli pneumonia Respiratory Research 12/1/2010 [PMID: 20633248]
Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Yoshioka T, Ogawa Y, Imamaki H, Kusakabe T, Ebihara K, Omata M, Satoh N, Sugawara A, Barasch J, Nakao K Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int., 2008-10-01;75(3):285-94. 2008-10-01 [PMID: 19148153] (IHC-P, Western Blot, Mouse)	IHC-P, Western Blot	Mouse
Lee S, Park JY, Lee WH, Kim H, Park HC, Mori K, Suk K Lipocalin-2 is an autocrine mediator of reactive astrocytosis. J. Neurosci., 2009-01-07;29(1):234-49. 2009-01-07 [PMID: 19129400] (Western Blot, Mouse)	Western Blot	Mouse
Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes, 2007-07-16;56(10):2533-40. 2007-07-16 [PMID: 17639021] (Western Blot, Mouse)	Western Blot	Mouse
Andre E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, Lentner B, Reinhard C, Schulz H, Wjst M Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung. Eur. Respir. J., 2006-04-26;28(2):275-85. 2006-04-26 [PMID: 16641123] (IHC-Fr, Mouse)	IHC-Fr	Mouse
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Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC	Mouse	05/03/2017	View Summary Application Immunohistochemistry Sample Tested skin tumor Species Mouse
Enlarge	5 reviewed by: Qi Miao	ICC	Mouse	05/03/2017	View Summary Application Immunocytochemistry Sample Tested Mouse Keratinocytes,mouse skin Species Mouse

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• Lipocalin-2/NGAL Antibodies
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• Lipocalin-2/NGAL ELISAs
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