LIF Antibody (39N7D10) - BSA Free

Lif has long been recognized as a cytokine which promotes murine germ cell growth in the absence of feeder cell layers in mouse cells (1-3)Characterized initially as an inhibitor of differentiation in M1 murine monocytic leukemia lines (hence the name Leukemia Inhibitory Factor),Lif is now recognized as a key factor for maintaining stem cells in the undifferentiated state- at least in mouse embryonic stem cells (4)Acting through the Lif receptor and the induced activation of STAT3, murine ESCs can be maintained in vitro in undifferentiated stateHowever, human ESCs, although functionally stimulated with Lif, are not similarly maintained as undifferentiatedThis illustrates a different functional program for Lif in mice and humans in maintenance of stem cellsAn IL-6 family member, Lif is an important pleiotropic cytokine with activity on cells of hematopoietic and non-hematopoietic origin.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-27406	Applications	Species
Kakae, M;Nakajima, H;Tobori, S;Kawashita, A;Miyanohara, J;Morishima, M;Nagayasu, K;Nakagawa, T;Shigetomi, E;Koizumi, S;Mori, Y;Kaneko, S;Shirakawa, H; The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production Science advances 2023-07-21 [PMID: 37478173]
Yue X, Wang J, Chang CY et al. Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis Cell death & disease [PMID: 35440095] (IF/IHC, Human)	IF/IHC	Human
Wang H, Si S, Jiang M Et Al. Leukemia inhibitory factor is involved in the pathogenesis of NSCLC through activation of the STAT3 signaling pathway Oncology Letters 2021-07-14 [PMID: 34386085] (WB, IHC-P)	WB, IHC-P
Wang H, Wang J, Zhao Y et al. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome Cell Death Dis 2020-07-27 [PMID: 32719388] (IHC-P, ICC/IF, Human)	IHC-P, ICC/IF	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Human	06/02/2019	View Summary Application Western Blot Sample Tested Human T cells Species Human Lot 02094407-04 Comments Comments Samples prepapred in SDS-PAge sampel buffer at 65*C for 10 minutes.

Array NBP2-27406

• LIF Antibodies
• LIF ELISA Kit
• LIF Lysate
• LIF Proteins
• LIF Proteins and Enzymes
• LIF ELISAs