LAMTOR1 Antibody

Manufactured by Genomic Antibody Technology™. GAT FAQs

c11orf59/LAMTOR1 (ragulator complex protein LAMTOR1 or PDRO), a part of Ragulator complex which contains LAMTOR1-5, is a relatively novel lapidated protein adaptor of the lysosomal membrane which senses and integrates a diverse array of cellular signals, with mTOR kinase activity within the complex being influenced by a variety of nutrients e.g. amino acids, glucose etc., oxygen status, cellular energy levels, and many secreted growth factors such as cytokines and hormones, including insulin. Ragulator is activated by amino acids through a mechanism involving lysosomal V-ATPase, and it functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Ragulator (activated) and Rag GTPases function as a scaffold that recruits mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes and is also required for late endosomes/lysosomes biogenesis. It regulates both the recycling of receptors through endosomes and MAPK signaling pathway through recruitment of some of its components to late endosomes. It implicates in cholesterol homeostasis for regulating LDL uptake and cholesterol release from late endosomes/lysosomes, and may play a role in RHOA activation. LAMTOR1 deregulation is observed in certain pathologies including cancer, diabetes and neurodegenerative diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	03/26/2018	View Summary Application Western Blot Sample Tested MEF whole cell lysate Species Mouse Lot A-1 Comments Comments Lysis buffer: 2x Laemmli buffer 20 µg protein /well Ab dilution: 1:1000 in milk-PBST

Array NBP1-71689

• LAMTOR1 Antibodies
• LAMTOR1 Lysate
• LAMTOR1 Protein