Kininogen Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using H00003827-D01P	Applications	Species
Xu J, Fang J, Cheng Z et al. Overexpression of the Kininogen-1 inhibits proliferation and induces apoptosis of glioma cells. J Exp Clin Cancer Res 2018-08-02 [PMID: 30068373]
Tursiella ML, Taylor SL, Schmaljohn CS. et al. Protocols to Assess Coagulation Following In Vitro Infection with Hemorrhagic Fever Viruses. Methods Mol Biol 2017-10-07 [PMID: 28986851]
Taylor SL, Wahl-Jensen V, Copeland AM et al. Endothelial Cell Permeability during Hantavirus Infection Involves Factor XII-Dependent Increased Activation of the Kallikrein-Kinin System. PLoS Pathog. 2013-07-18 [PMID: 23874198]

Array H00003827-D01P

• Kininogen Antibodies
• Kininogen Antibody Pair
• Kininogen ELISA Kit
• Kininogen Lysate
• Kininogen Proteins
• Kininogen Proteins and Enzymes
• Kininogen ELISA