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Integrin beta 2/CD18 Antibody (M18/2) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, Func, IHC, IP, CyTOF-ready
Clone
M18/2
Clonality
Monoclonal
Host
Rat
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Allophycocyanin/Cy7
NBP1-41272APCCY7
DyLight 594
NBP1-41272DL594
HRP
NBP1-41272H
Janelia Fluor 549
NBP1-41272JF549
PE/Atto594
NBP1-41272PEATT594
PE/Cy5.5
NBP1-41272PECY55
PE/Cy7
NBP1-41272PECY7
Unconjugated
NBP1-41272
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-41272
Azide and BSA Free
NBP1-41272
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Integrin beta 2/CD18 Antibody (M18/2) [Janelia Fluor® 646] Summary

Immunogen
Murine cytotoxic T cell glycoproteins
Specificity
The rat monoclonal antibody M18/2 recognizes CD18 antigen (integrin beta2 subunit; beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
ITGB2
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Functional
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Integrin beta 2/CD18 Antibody (M18/2) [Janelia Fluor® 646]

  • 959 beta subunit precursor)10
  • CD18 antigen
  • CD18
  • CD18beta 2
  • cell surface adhesion glycoprotein (LFA-1
  • CR3
  • Integrin beta 2
  • integrin beta-2
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • ITGB2
  • LAD
  • LCAMB
  • leukocyte cell adhesion molecule CD18
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • LFA-1 beta
  • LFA-1
  • MAC-1 beta
  • MF17
  • MFI7
  • P150
  • p150,95 beta

Background

CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.
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Bioinformatics

Gene Symbol ITGB2