Integrin alpha L/CD11a Antibody (345913) [Fluorescein] Summary
Immunogen |
Chinese hamster ovary cell line CHO-derived recombinant human Integrin alpha L/CD11a Tyr26-Met1089 (Tyr660Ile) Accession # CAA68747 |
Specificity |
Detects human Integrin alpha L/CD11a in Western blots. |
Source |
N/A |
Isotype |
IgG1 |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
ITGAL |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry 10 uL/10^6 cells
|
Packaging, Storage & Formulations
Storage |
Protect from light. Do not freeze.- 12 months from date of receipt, 2 to 8 °C as supplied.
|
Buffer |
Supplied in a saline solution containing BSA and Sodium Azide. |
Preservative |
Sodium Azide |
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Integrin alpha L/CD11a Antibody (345913) [Fluorescein]
Background
Integrin subunit alpha L/CD11a is a 180 kDa type I TM glycoprotein that interacts only with Integrin beta 2/CD18 to form LFA-1, a leukocyte adhesion protein which binds endothelial cell ICAM-1 through -4. Human Integrin alpha L contains a 1064 aa extracellular domain (ECD), a 20 aa TM sequence and a 58 aa cytoplasmic domain. The ECD contains seven repeats that form a beta-propeller structure and one inserted vWA domain (I domain) containing a metal ion-dependent adhesion site (MIDAS). Human and mouse Integrin alpha L ECD share 74% aa identity. CD11a has two splice variants, one which contains a 53 aa insert after Gln954, and a second which shows a deletion of aa 110-192.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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