Home » IL-18R alpha/IL-1 R5 » IL-18R alpha/IL-1 R5 Antibodies » IL-18R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin]
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IL-18R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin]

 (8 Publications)
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Human peripheral blood mononuclear cells (PBMCs) treated with 10 ng/mL Recombinant Human IL-2 (Catalog # 202-IL) and 5 µg/mL PHA for 48 hours were stained with Mouse Anti-Human IL-18 Ra/IL-1 R5 PE-conjugated Monoclonal Antibody (Catalog # FAB840P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Human peripheral blood mononuclear cells (PBMCs) treated with 10 ng/mL Recombinant Human IL-2 (Catalog # 202-IL) and 5 µg/mL PHA for 48 hours were stained with Mouse Anti-Human IL-18 Ra/IL-1 R5 PE-conjugated Monoclonal ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
70625
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB840U-100UG
Alexa Fluor 405
FAB840V-100UG
Alexa Fluor 488
FAB840G-100
Alexa Fluor 488
FAB840G-025
Alexa Fluor 532
FAB840X
Alexa Fluor 594
FAB840T-100UG
Alexa Fluor 647
FAB840R-100UG
Alexa Fluor 700
FAB840N-100UG
Alexa Fluor 750
FAB840S-100UG
Allophycocyanin
FAB840A-025
Allophycocyanin
FAB840A-100
Allophycocyanin/Cy7
FAB840APCCY7
Biotin
FAB840B
CoraFluor 1
FAB840CL1
DyLight 350
FAB840D
DyLight 405
FAB840E
DyLight 488
FAB840K
DyLight 550
FAB840L
DyLight 594
FAB840M
DyLight 650
FAB840W
DyLight 680
FAB840Y
DyLight 755
FAB840Z
FITC
FAB840F
HRP
FAB840H
Janelia Fluor 525
FAB840JF525
Janelia Fluor 549
FAB840I
Janelia Fluor 585
FAB840JF585
Janelia Fluor 635
FAB840JF635
Janelia Fluor 646
FAB840J
Janelia Fluor 669
FAB840JF669
PE/Atto594
FAB840PEATT594
PE/Cy5.5
FAB840PECY55
PE/Cy7
FAB840PECY7
Phycoerythrin
FAB840P-025
Unconjugated
MAB840-100
mFluor Violet 450 SE
FAB840MFV450
mFluor Violet 500 SE
FAB840MFV500
mFluor Violet 610 SE
FAB840MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB840-100
Carrier Free
FAB840A-100
Carrier Free
FAB840G-100
Carrier Free
FAB840A-025
Carrier Free
FAB840G-025
Carrier Free
FAB840P-025
Carrier Free
MAB840-SP
Carrier Free
MAB840-500
Carrier Free
MAB840-100
Carrier Free
FAB840V-100UG
Carrier Free
FAB840U-100UG
Carrier Free
FAB840T-100UG
Carrier Free
FAB840S-100UG
Carrier Free
FAB840R-100UG
Carrier Free
FAB840N-100UG
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IL-18R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL‑18 R alpha /IL-1 R5
Glu20-Arg329
Accession # Q13478
Specificity
Detects human IL-18 R alpha /IL-1 R5 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-1 RI, rhIL-1 RII, rhIL‑1 R3, rhIL-1 R4, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, rhIL-1 R9, rhSIGIRR or recombinant mouse IL-18 R alpha is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL18R1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB840P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-18R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin]

  • CD218a
  • CD218a;CDw218a;IL18R1;IL18RA;IL-18Ralpha;IL-18R-alpha;IL18Ralpha2;IL1RRP;IL-1Rrp;Interleukin-18 receptor 1
  • IL-1 R5
  • IL-1 Rrp
  • IL-18 R alpha
  • IL-18 R1
  • IL18R alpha
  • IL18R1
  • IL-18Ra

Background

Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also known as IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also known as IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. Although IL-18 R alpha by itself binds IL-18 with low affinity and IL-18 R beta does not bind IL-18 in vitro, co-expression of IL‑18 R alpha and IL‑18 R beta is required for high affinity binding and IL-18 responsiveness. Human IL-18 R cDNA encodes a 541 amino acid (aa) precursor type I membrane protein with a hydrophobic signal, an extracellular domain comprised of three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic region of approximately 200 aa. Human and mouse IL-18 R share 65% amino acid sequence homology. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta.

  1. Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.
  2. Torigoe, K. et al. (1997) J. Biol. Chem. 272:25737.
  3. Born, T.L. et al. (1998) J. Biol. Chem. 273:29445.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IL-18R alpha/IL-1
R5 Antibody (70625) [ ...
FAB840P
IL-18R alpha/IL-1 R5 Antibody (70625) [Phycoerythrin]
Species: Hu
Applications: Flow

Publications for IL-18R alpha/IL-1 R5 Antibody (FAB840P)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


Filter By Application
Flow Cytometry
(6)
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Human
(6)
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Showing Publications 1 - 8 of 8.
Publications using FAB840P Applications Species
Avishai Shemesh, Harry Pickering, Kole T. Roybal, Lewis L. Lanier Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion Journal of Experimental Medicine 8/1/2022 [PMID: 35758909]
Sundstrom P, Ahlmanner F, Akeus P, Sundquist M, Alsen S, Yrlid U, Borjesson L, Sjoling A, Gustavsson B, Wong S, Quiding-Jarbrink M Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-gamma. J Immunol, 2015-08-21;195(7):3472-81. 2015-08-21 [PMID: 26297765] (Flow Cytometry, Human) Flow Cytometry Human
Uzan B, Poglio S, Gerby B, Wu C, Gross J, Armstrong F, Calvo J, Cahu X, Deswarte C, Dumont F, Passaro D, Besnard-Guerin C, Leblanc T, Baruchel A, Landman-Parker J, Ballerini P, Baud V, Ghysdael J, Baleydier F, Porteu F, Pflumio F Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression. EMBO Mol Med, 2014-04-06;6(6):821-34. 2014-04-06 [PMID: 24778454] (Flow Cytometry, Human) Flow Cytometry Human
Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer's disease. Cytokine, 2012-11-30;61(2):360-3. 2012-11-30 [PMID: 23201485] (Flow Cytometry, Human) Flow Cytometry Human
Rachel B. Munk, Katsuki Sugiyama, Paritosh Ghosh, Carl Y. Sasaki, Louis Rezanka, Kasturi Banerjee et al. Antigen-Independent IFN-gamma Production by Human Naïve CD4+ T Cells Activated by IL-12 Plus IL-18 PLoS ONE 5/10/2011 [PMID: 21572994]
Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, Milder M, Le Bourhis L, Soudais C, Treiner E, Lantz O Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood, 2010-11-17;117(4):1250-9. 2010-11-17 [PMID: 21084709] (Flow Cytometry, Human) Flow Cytometry Human
De Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, Prakken BJ Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum., 2009-09-01;60(9):2782-93. 2009-09-01 [PMID: 19714583] (Flow Cytometry, Human) Flow Cytometry Human
Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J. Immunol., 2003-06-01;170(11):5571-7. 2003-06-01 [PMID: 12759435] (Flow Cytometry, Human) Flow Cytometry Human

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Bioinformatics

Gene Symbol IL18R1
Uniprot