Home » IL-18/IL-1F4 » IL-18 Antibodies » IL-18/IL-1F4 Antibody (74801) [Alexa Fluor® 405]
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IL-18/IL-1F4 Antibody (74801) [Alexa Fluor® 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
74801
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 405
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC646U-100UG
Alexa Fluor 488
IC646G-100
Alexa Fluor 532
FAB646X
Alexa Fluor 594
IC646T-100UG
Alexa Fluor 647
IC646R-100UG
Alexa Fluor 700
IC646N-100UG
Alexa Fluor 750
IC646S-100UG
Allophycocyanin
FAB646A
Biotin
FAB646B
DyLight 350
FAB646D
DyLight 405
FAB646E
DyLight 488
FAB646K
DyLight 550
FAB646L
DyLight 594
FAB646M
DyLight 650
FAB646W
DyLight 680
FAB646Y
DyLight 755
FAB646Z
FITC
FAB646F
HRP
FAB646H
Janelia Fluor 525
FAB646JF525
Janelia Fluor 549
FAB646I
Janelia Fluor 585
FAB646JF585
Janelia Fluor 635
FAB646JF635
Janelia Fluor 646
FAB646J
Janelia Fluor 669
FAB646JF669
PerCP
FAB646C
Phycoerythrin
IC646P
Unconjugated
MAB646
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB646
Carrier Free
MAB646
Carrier Free
MAB646-SP
Carrier Free
IC646P
Carrier Free
IC646S-100UG
Carrier Free
IC646R-100UG
Carrier Free
IC646N-100UG
Carrier Free
IC646U-100UG
Carrier Free
IC646T-100UG
Carrier Free
IC646G-100
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IL-18/IL-1F4 Antibody (74801) [Alexa Fluor® 405] Summary

Immunogen
E. coli-derived recombinant human IL‑18/IL‑1F4
Accession # Q14116
Specificity
Detects the pro region of human IL-18/IL-1F4 in direct ELISAs and Western blots. Does not cross‑react with recombinant human IL-18, recombinant mouse IL-18 or recombinant rat IL-18.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL18
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-18/IL-1F4 Antibody (74801) [Alexa Fluor® 405]

  • Iboctadekin
  • IFN-gamma-inducing factor
  • IGIF
  • IGIFIL-1 gamma
  • IL18
  • IL-18
  • IL-18MGC12320
  • IL-1F4
  • IL1F4iboctadekin
  • IL-1g
  • Interferon gamma-inducing factor
  • interleukin 18 (interferon-gamma-inducing factor)
  • Interleukin-1 gamma
  • interleukin-18

Background

Pro-IL-18 (pro-Interleukin 18; also pro-IGIF and pro-IL-1 gamma ) is a 24 kDa member of the IL-1 family of molecules. It is widely expressed, being produced by keratinocytes, intestinal epithelium, T cells, macrophages and osteoblasts. Human Pro-IL-18 is 193 amino acids (aa) in length. Although mature IL-18 induces IFN-gamma secretion by NK and T cells, Pro-IL-18 appears to have little intrinsic activity. Generally, active IL-18 is considered to arise from caspase-1 cleavage of Pro-IL-18 between Asp36-Tyr37. This generates an 18 kDa mature C-terminal fragment, and a 4 kDa (predicted) N-terminal prosegment that runs at 6 kDa in SDS-PAGE. Other proteases are known to process Pro-IL-18. Caspase-3 cleavage after Asp68 generates an inactive 14 kDa mature segment, Merpin beta -subunit cleavage after Asn52 generates a marginally active 17 kDa mature segment, while parasite Cys protease cleavage after Val47 generates an inactive 17 kDa mature molecule. One splice variant shows a deletion of aa 27-30. Over aa 2-36, human Pro-IL-18 shares 63% aa identity with mouse Pro-IL-18.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL18
Uniprot