IL-15 Antibody [Biotin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 (1 - 3). Mature mouse IL-15 shares 70% and 96% amino acid sequence identity with human and rat IL-15, respectively. Alternate splicing generates isoforms of IL-15 with either a long or short signal peptide (LSP or SSP), and the SSP isoform is retained intracellularly (4). IL-15 binds with high affinity to IL-15 R alpha (5). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain ( gamma c) which are also subunits of the IL-2 receptor complex (1, 6). IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface (7, 8). The dominant mechanism of IL-15 action is known as transpresentation in which IL-15 and IL-15 R alpha are coordinately expressed on the surface of one cell and interact with complexes of IL-2 R beta / gamma c on adjacent cells (9). This enables cells to respond to IL-15 even if they do not express IL-15 R alpha (8, 10). Soluble IL-15-binding forms of IL-15 R alpha can be generated by proteolytic shedding or alternate splicing (11 - 13). These molecules retain the ability to bind tightly to IL-15 and can either inhibit or augment IL-15 function (5, 12, 13). Consistent with its shared use of IL-2 receptor subunits, IL-15 induces IL-2-like effects in lymphocyte development and homeostasis (3). It is particularly important for the maintenance and activation of NK cells and CD8+ memory T cells (3). IL-15 also exerts pleiotropic effects on other hematopoietic cells and non-immune cells (2). Ligation of membrane-associated IL-15/IL-15 R alpha complexes induces reverse signaling that promotes cellular adhesion, tyrosine phosphorylation of intracellular proteins, and cytokine secretion by the IL-15/IL-15 R alpha expressing cells (14, 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: ELISA Development, Flow Cytometry.

Showing Publications 1 - 6 of 6.

Publications using BAF447	Applications	Species
Bingtao Tang, Zong Sheng Guo, David L. Bartlett, David Z. Yan, Claire P. Schane, Diana L. Thomas et al. Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma Clinical Cancer Research 5/1/2020 [PMID: 32019860]
Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes. J. Immunol., 2012-09-19;189(9):4237-46. 2012-09-19 [PMID: 22993203] (ELISA Development, Mouse)	ELISA Development	Mouse
Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J. Immunol., 2009-06-15;182(12):7398-407. 2009-06-15 [PMID: 19494262] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Rowley J, Monie A, Hung CF, Wu TC Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans. J. Immunol., 2008-12-15;181(12):8237-47. 2008-12-15 [PMID: 19050240] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Mortier E, Woo T, Advincula R, Gozalo S, Ma A IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J. Exp. Med., 2008-05-05;205(5):1213-25. 2008-05-05 [PMID: 18458113] (ELISA Development, Mouse)	ELISA Development	Mouse
Watkins SK, Egilmez NK, Suttles J, Stout RD IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J. Immunol., 2007-02-01;178(3):1357-62. 2007-02-01 [PMID: 17237382] (ELISA Development, Flow Cytometry, Mouse)	ELISA Development, Flow Cytometry	Mouse

Array BAF447

• IL-15 Antibodies
• IL-15 Antibody Pair
• IL-15 ELISA Kits
• IL-15 Lysate
• IL-15 Proteins
• IL-15 ELISAs
• IL-15 Proteins and Enzymes