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IL-12 R beta 1 Antibody (69310) [Unconjugated]

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Daudi cells were stained with Mouse Anti-Human IL‑12 R beta 1 Monoclonal Antibody (Catalog # MAB839, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram) followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). View our protocol for Staining Membrane-associated Proteins.
Daudi cells were stained with Mouse Anti-Human IL‑12 R beta 1 Monoclonal Antibody (Catalog # MAB839, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram) followed by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
69310
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB839U-100UG
Alexa Fluor 405
FAB839V-100UG
Alexa Fluor 488
FAB839G-100UG
Alexa Fluor 532
FAB839X
Alexa Fluor 594
FAB839T-100UG
Alexa Fluor 647
FAB839R-100UG
Alexa Fluor 750
FAB839S-100UG
Allophycocyanin
FAB839A-025
Allophycocyanin
FAB839A-100
Allophycocyanin/Cy7
FAB839APCCY7
Biotin
FAB839B
DyLight 350
FAB839D
DyLight 405
FAB839E
DyLight 488
FAB839K
DyLight 550
FAB839L
DyLight 594
FAB839M
DyLight 650
FAB839W
DyLight 680
FAB839Y
DyLight 755
FAB839Z
HRP
FAB839H
Janelia Fluor 525
FAB839JF525
Janelia Fluor 549
FAB839I
Janelia Fluor 646
FAB839J
Janelia Fluor 669
FAB839JF669
PE/Atto594
FAB839PEATT594
PE/Cy5.5
FAB839PECY55
PE/Cy7
FAB839PECY7
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
FAB839A-100
Carrier Free
FAB839A-025
Carrier Free
MAB839-SP
Carrier Free
FAB839V-100UG
Carrier Free
FAB839U-100UG
Carrier Free
FAB839T-100UG
Carrier Free
FAB839S-100UG
Carrier Free
FAB839R-100UG
Carrier Free
FAB839G-100UG
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IL-12 R beta 1 Antibody (69310) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL-12 R beta 1
Cys24-Glu540
Accession # P42701
Specificity
Detects human IL-12 R beta 1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse IL-12 R beta 1 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL12RB1
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
Publications
Read Publications using
MAB839 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-12 R beta 1 Antibody (69310) [Unconjugated]

  • CD212 antigen
  • CD212
  • IL-12 R beta 1
  • IL-12 receptor beta component
  • IL-12 receptor subunit beta-1
  • IL12R beta 1
  • IL-12R subunit beta-1
  • IL12R
  • IL12RB
  • IL12RB1
  • IL-12Rb1
  • IL-12R-BETA1
  • IL-12R-beta-1
  • interleukin 12 receptor, beta 1
  • interleukin-12 receptor beta-1 chain
  • interleukin-12 receptor subunit beta-1
  • MGC34454

Background

Interleukin12 (IL-12) is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. The biological activities of IL-12 are mediated through the high-affinity receptor complex composed of two subunits designated IL-12 R beta 1 and IL-12 R beta 2. Individually, IL-12 R beta 1 and IL-12 R beta 2 bind IL‑12 with low affinity. Co-expression of both subunits confers high-affinity binding and is required for IL-12 activity. Both IL-12 receptor subunits are type I transmembrane proteins that share similarities with the gp130/G-CSF R subgroup in the cytokine receptor superfamily. IL-12 R beta 1 cDNA encodes a 662 amino acid (aa) protein with a putative 23 aa signal peptide that is cleaved to generate the mature protein with a 522 aa extracellular domain, a 25 aa transmembrane domain and a 92 aa cytoplasmic region. Expression of IL-12 R beta 1 is detected in activated T cells, NK cells and B cells. The expression of IL‑12 R beta 2 is more restricted and appears to be limited to Th2 cells.

  1. Gately, M.K. et al. (1998) Annu. Rev. Immunol. 16:495.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IL-12 R beta 1
Antibody (69310) [Unc ...
MAB839
IL-12 R beta 1 Antibody (69310) [Unconjugated]
Species: Hu
Applications: Flow, CyTOF-ready

Publications for IL-12 R beta 1 Antibody (MAB839)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


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Flow Cytometry
(2)
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(2)
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Bioinformatics

Gene Symbol IL12RB1
Uniprot