IKK beta Antibody

NFkB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFk B is negatively modulated by the inhibitory proteins Ik-B. In turn Ik-B is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b which phosphorylate Ik-B leading to its degradation and the resulting translocation of NFk B to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF-a , endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publication 1 - 1 of 1.

Publication using NB600-477	Applications	Species
Liu Y, Liu X, Hao W et al. IKKbeta deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J Neurosci 2014-09-24 [PMID: 25253847]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: alex liu	IF	Mouse	12/19/2014	View Summary Application Immunofluorescence Species Mouse

Array NB600-477

• IKK beta Antibodies
• IKK beta ELISA Kits
• IKK beta Lysate
• IKK beta Proteins