Human Phospho-EGFR (Y1068) DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The EGF R subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER-1, ErbB1, or ErbB), ErbB2 (Neu, HER-2), ErbB3 (HER-3), and ErbB4 (HER-4). All family members are type I transmembrane glycoproteins with an extracellular ligand binding domain containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain followed by multiple tyrosine autophosphorylation sites. The human EGF R cDNA encodes a 1210 amino acid (aa) precursor with a 24 aa signal peptide, a 621 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 542 aa cytoplasmic domain. Soluble receptors consisting of the extracellular ligand binding domain are generated by alternate splicing in human and mouse. Within the ECD, human EGF R shares 88% aa sequence identity with mouse and rat EGF R. It shares 43% - 44% aa sequence identity with the ECD of human ErbB2, ErbB3, and ErbB4. EGF R binds a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, and epigen. Ligand binding induces EGF R homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, heterodimerization tyrosine phosphorylation and cell signaling. EGF R can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGF R signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGF R is overexpressed in a wide variety of tumors and is the target of several anti-cancer drugs.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 4 of 4.

Publications using DYC3570-2	Applications	Species
CW Weng, CH Wei, JY Tsai, YH Lai, GC Chang, JJW Chen Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth International Journal of Molecular Sciences, 2022-03-23;23(7):. 2022-03-23 [PMID: 35408854] (Human)		Human
Knoop , K A, McDonald , K G, McCrate , S, McDole , J R, Newberry , R D Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon. Mucosal Immunol, 2014-07-09;8(1):198-210. 2014-07-09 [PMID: 25005358] (Human)		Human
Derer , Stefanie, Bauer , Philip, Lohse , Stefan, Scheel , Andreas, Berger , Sven, Kellner , Christia, Peipp , Matthias, Valerius , Thomas Impact of epidermal growth factor receptor (EGFR) cell surface expression levels on effector mechanisms of EGFR antibodies. J Immunol, 2012-10-24;189(11):5230-9. 2012-10-24 [PMID: 23100515] (Human)		Human
Xu L, Nilsson MB, Saintigny P, Cascone T, Herynk MH, Du Z, Nikolinakos PG, Yang Y, Prudkin L, Liu D, Lee JJ, Johnson FM, Wong KK, Girard L, Gazdar AF, Minna JD, Kurie JM, Wistuba II, Heymach JV Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells. Oncogene, 2010-02-15;29(18):2616-27. 2010-02-15 [PMID: 20154724] (Human)		Human

Array DYC3570-2

• EGFR Antibodies
• EGFR Antibody Pair
• EGFR Lysate
• EGFR Proteins
• EGFR ELISAs
• EGFR Proteins and Enzymes