Human IL-22 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-22 (Interleukin-22) is a cytokine that induces the production of reactive oxygen species, IL-6, IL-10, and TNF-alpha as well as neutrophil infiltration during inflammation. It also supports the integrity of epithelial barriers and induces epithelial cell proliferation during wound healing. IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. IL-10 R beta is a shared component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29. IL-22 additionally binds to IL-22BP which blocks the interaction of IL-22 with IL-22 R.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using D2200	Applications	Species
Nawrocka-Millward, S;Biegus, J;Fudim, M;Guzik, M;Iwanek, G;Ponikowski, P;Zymli?ski, R; The role of urine chloride in acute heart failure Scientific reports 2024-06-18 [PMID: 38890417] (Human)		Human
K Wolk, D Wilsmann-T, K Witte, TC Brembach, C Kromer, S Gerdes, K Ghoreschi, K Reich, R Mössner, R Sabat Interleukin-19 Levels Are Increased in Palmoplantar Pustulosis and Reduced following Apremilast Treatment International Journal of Molecular Sciences, 2023-01-09;24(2):. 2023-01-09 [PMID: 36674793] (Human)		Human
R Kishi, S Toyama, M Tominaga, Y Kamata, E Komiya, T Kaneko, Y Suga, K Takamori Effects of Dupilumab on Itch-Related Events in Atopic Dermatitis: Implications for Assessing Treatment Efficacy in Clinical Practice Cells, 2023-01-05;12(2):. 2023-01-05 [PMID: 36672173] (Human)		Human
M Garus, A Zdanowicz, M Fudim, R Zymli?ski, P Niewi?ski, B Paleczny, M Rosiek-Bie, G Iwanek, P Ponikowski, J Biegus Clinical determinants and prognostic significance of hypocapnia in acute heart failure Scientific Reports, 2022-10-07;12(1):16889. 2022-10-07 [PMID: 36207364] (Human)		Human
O Farc, I Berindan-N, F Zaharie, L Budisan, O Zanoaga, V Cristea A role for serum cytokines and cell adhesion molecules in the non-invasive diagnosis of colorectal cancer Oncology Letters, 2022-07-26;24(3):323. 2022-07-26 [PMID: 35949613] (Human)		Human
U Förster-Ru, AJ Szczepek, G Pierchalla, JW Fluhr, M Artuc, T Zuberbier, C Bachert, H Olze Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis Journal of personalized medicine, 2022-04-18;12(4):. 2022-04-18 [PMID: 35455762] (Human)		Human
C Gar, B Thorand, C Herder, C Sujana, M Heier, C Meisinger, A Peters, W Koenig, W Rathmann, M Roden, M Stumvoll, H Maalmi, T Meitinger, H Then, J Seissler, C Then Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study PLoS ONE, 2022-01-06;17(1):e0262330. 2022-01-06 [PMID: 34990470] (Human)		Human
S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure Biomolecules, 2021-11-16;11(11):. 2021-11-16 [PMID: 34827701] (Human)		Human
L Bertran, M Portillo-C, S Martínez, C Aguilar, M Lopez-Dupl, D Riesco, J Binetti, M Vives, F Sabench, D Del Castil, C Richart, T Auguet Expression of Jejunal Taste Receptors in Women with Morbid Obesity Nutrients, 2021-07-16;13(7):. 2021-07-16 [PMID: 34371946] (Human)		Human
M Raundhal, S Ghosh, SA Myers, MS Cuoco, M Singer, SA Carr, SS Waikar, JV Bonventre, J Ritz, RM Stone, DP Steensma, A Regev, LH Glimcher Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias Nature Immunology, 2021-03-22;0(0):. 2021-03-22 [PMID: 33753942] (Human)		Human
T Auguet, L Bertran, J Binetti, C Aguilar, S Martínez, F Sabench, JM Lopez-Dupl, JA Porras, D Riesco, D Del Castil, C Richart Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis Int J Mol Sci, 2020-06-11;21(11):. 2020-06-11 [PMID: 32545403] (Human)		Human
Y He, Y Yang, J Xu, Y Liao, L Liu, L Deng, X Xiong IL22 drives cutaneous melanoma cell proliferation, migration and invasion through activation of miR-181/STAT3/AKT axis J Cancer, 2020-02-19;11(9):2679-2687. 2020-02-19 [PMID: 32201538] (Human)		Human
Z Mei, K Zhang, AK Lam, J Huang, F Qiu, B Qiao, Y Zhang MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma Cancer Med, 2019-12-04;0(0):. 2019-12-04 [PMID: 31800160] (Human)		Human
A Federico, M Dallio, M Masarone, AG Gravina, R Di Sarno, C Tuccillo, V Cossiga, S Lama, P Stiuso, F Morisco, M Persico, C Loguercio Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients Oxid Med Cell Longev, 2019;2019(0):8742075. 2019 [PMID: 31737175] (Human)		Human
G Ding, Y Ming, Y Zhang lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells Gastroenterol Res Pract, 2019-10-07;2019(0):8154692. 2019-10-07 [PMID: 31687015] (Human)		Human
S Clayton, E Cauble, A Kumar, N Patil, D Ledford, N Kolliputi, MF Lopes-Vire, D Castell, J Richter Plasma levels of TNF-?, IL-6, IFN-?, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD) BMC Gastroenterol, 2019-02-11;19(1):28. 2019-02-11 [PMID: 30744559] (Human)		Human
C Guida, SD Stephen, M Watson, N Dempster, P Larraufie, T Marjot, T Cargill, L Rickers, M Pavlides, J Tomlinson, JFL Cobbold, CM Zhao, D Chen, F Gribble, F Reimann, R Gillies, B Sgromo, P Rorsman, JD Ryan, RD Ramracheya PYY plays a key role in the resolution of diabetes following bariatric surgery in humans EBioMedicine, 2019-01-11;0(0):. 2019-01-11 [PMID: 30639417] (Human)		Human
RJW Arts, SJCFM Moorlag, B Novakovic, Y Li, SY Wang, M Oosting, V Kumar, RJ Xavier, C Wijmenga, LAB Joosten, CBEM Reusken, CS Benn, P Aaby, MP Koopmans, HG Stunnenber, R van Crevel, MG Netea BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity Cell Host Microbe, 2018-01-10;23(1):89-100.e5. 2018-01-10 [PMID: 29324233] (Human)		Human
VR Ribeiro, M Romao-Veig, GG Romagnoli, ML Matias, PR Nunes, VTM Borges, JC Peracoli, MTS Peracoli Association between cytokine profile and transcription factors produced by T cells subsets in early and late-onset preeclampsia Immunology, 2017-06-19;0(0):. 2017-06-19 [PMID: 28502089] (Human)		Human
NP Kumar, VV Banurekha, D Nair, S Babu Diminished plasma levels of common ?-chain cytokines in pulmonary tuberculosis and reversal following treatment PLoS ONE, 2017-04-27;12(4):e0176495. 2017-04-27 [PMID: 28448542] (Human)		Human
YW Ji, SK Mittal, HS Hwang, EJ Chang, JH Lee, Y Seo, A Yeo, H Noh, HS Lee, SK Chauhan, HK Lee Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation Mucosal Immunol, 2017-01-04;0(0):. 2017-01-04 [PMID: 28051088] (Human, Mouse)		Human, Mouse
Ketao Lan Correlation of Tc17 cells at early stages after allogeneic hematopoietic stem cell transplantation with acute graft-versus-host disease Int. Immunopharmacol., 2016-11-12;41(0):122-126. 2016-11-12 [PMID: 27846420] (Human)		Human
Alterations in the Fecal Microbiota of Patients with HIV-1 Infection: An Observational Study in A Chinese Population Sci Rep, 2016-08-01;6(0):30673. 2016-08-01 [PMID: 27477587] (Human)		Human
Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response. PLoS ONE, 2014-01-28;9(1):e86466. 2014-01-28 [PMID: 24489729] (Human)		Human
Loubaki L, Hadj-Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, Aoudjit F, Chakir J Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature. PLoS ONE, 2013-12-05;8(12):e81983. 2013-12-05 [PMID: 24349168] (Human)		Human
Kleinnijenhuis J, Quintin J, Preijers F, Benn C, Joosten L, Jacobs C, van Loenhout J, Xavier R, Aaby P, van der Meer J, van Crevel R, Netea M Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity. J Innate Immun, 2013-10-30;6(2):152-8. 2013-10-30 [PMID: 24192057] (Human)		Human
Tang , Xin-Zi, Jo , Juandy, Tan , Anthony, Sandalova , Elena, Chia , Adeline, Tan , Kai Chah, Lee , Kang Hoe, Gehring , Adam J, De Libero , Gennaro, Bertoletti , Antonio IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol, 2013-02-27;190(7):3142-52. 2013-02-27 [PMID: 23447689] (Human)		Human
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation. PLoS Biol, 2012-09-25;10(9):e1001395. 2012-09-25 [PMID: 23055831] (Human)		Human
Kronenberger B, Rudloff I, Bachmann M, Brunner F, Kapper L, Filmann N, Waidmann O, Herrmann E, Pfeilschifter J, Zeuzem S, Piiper A, Muhl H Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study. BMC Med, 2012-09-11;10(0):102. 2012-09-11 [PMID: 22967278] (Human)		Human
Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin. Cancer Res., 2011-11-02;17(24):7529-38. 2011-11-02 [PMID: 22048239] (Human)		Human
Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, Agron E, Chan CC, Klein ML, Chew E, Ferris F, Nussenblatt RB Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration. J Transl Med, 2011-07-15;9(0):111. 2011-07-15 [PMID: 21762495] (Human)		Human
Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients. Arch. Dermatol. Res., 2011-06-17;303(6):451-5. 2011-06-17 [PMID: 21681565] (Human)		Human
Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation. J. Invest. Dermatol., 2011-06-16;131(9):1838-44. 2011-06-16 [PMID: 21677670] (Human)		Human
Di Meglio P, Di Cesare A, Laggner U The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans. PLoS ONE, 2011-02-22;6(2):e17160. 2011-02-22 [PMID: 21364948] (Human)		Human
Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur. J. Immunol., 2010-09-01;40(9):2450-9. 2010-09-01 [PMID: 20706985] (Human)		Human
Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol., 2009-12-01;39(12):3570-81. 2009-12-01 [PMID: 19830738] (Human)		Human
Ziesche E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Muhl H Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin. Exp. Immunol., 2009-09-01;157(3):370-6. 2009-09-01 [PMID: 19664145] (Human)		Human
Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 2009-03-09;206(3):535-48. 2009-03-09 [PMID: 19273625] (Human)		Human
Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4. 2008-12-03 [PMID: 19056110] (Human)		Human
Pene J, Chevalier S, Preisser L, Venereau E, Guilleux MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol., 2008-06-01;180(0):7423. 2008-06-01 [PMID: 18490742] (Human)		Human
Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med., 2008-02-10;14(3):275-81. 2008-02-10 [PMID: 18264110] (Human)		Human
Dambacher J, Beigel F, Zitzmann K, Heeg MH, Goke B, Diepolder HM, Auernhammer CJ, Brand S The role of interleukin-22 in hepatitis C virus infection. Cytokine, 2008-01-11;41(3):209-16. 2008-01-11 [PMID: 18191408] (Human)		Human
Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Lohse P, Goke B, Brand S Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm. Bowel Dis., 2008-02-01;14(2):204-12. 2008-02-01 [PMID: 18022867] (Human)		Human
Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J. Immunol., 2007-05-01;178(9):5973-81. 2007-05-01 [PMID: 17442982] (Human)		Human
Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 2006-05-01;36(5):1309-23. 2006-05-01 [PMID: 16619290] (Human)		Human
Show All 45 Publications. Collapse Publications.

Array D2200

• IL-22 Antibodies
• IL-22 Antibody Pair
• IL-22 ELISA Kit
• IL-22 Lysate
• IL-22 Proteins
• IL-22 Proteins and Enzymes
• IL-22 ELISAs