Human Endostatin Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.

We have publications tested in 3 confirmed species: Human, Mouse, Goat.

Showing Publications 1 - 10 of 22. Show All 22 Publications. Collapse Publications.

Publications using DNST0	Applications	Species
FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019-06-21;4(10):1373-1386. 2019-06-21 [PMID: 31701047] (Human)		Human
YY Joo, JW Jang, SW Lee, SH Yoo, JH Kwon, SW Nam, SH Bae, JY Choi, SK Yoon Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression Sci Rep, 2019-06-24;9(1):9137. 2019-06-24 [PMID: 31235729] (Human)		Human
J Zhang, D Nie, K Williamson, JL Rocha, MV Hogan, JH Wang Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing J Tissue Eng, 2019-01-16;10(0):2.04173E+15. 2019-01-16 [PMID: 30728936] (Human)		Human
M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue Eur J Vasc Endovasc Surg, 2018-04-12;0(0):. 2018-04-12 [PMID: 29656960] (Human)		Human
Borghini A, Manetti M, Nacci F, Bellando-Randone S, Guiducci S, Matucci-Cerinic M, Ibba-Manneschi L, Weber E Systemic Sclerosis Sera Impair Angiogenic Performance of Dermal Microvascular Endothelial Cells: Therapeutic Implications of Cyclophosphamide. PLoS ONE, 2015-06-15;10(6):e0130166. 2015-06-15 [PMID: 26076019] (Human)		Human
Marek-Trzonkowska N, Kwieczynska A, Reiwer-Gostomska M, Kolinski T, Molisz A, Siebert J Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors. PLoS ONE, 2015-05-07;10(5):e0126190. 2015-05-07 [PMID: 25951297] (Human)		Human
Hutzen , Brian, Bid , Hemant K, Houghton , Peter J, Pierson , Christop, Powell , Kimerly, Bratasz , Anna, Raffel , Corey, Studebaker , Adam W Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin. BMC Cancer, 2014-03-19;14(0):206. 2014-03-19 [PMID: 24646176] (Human)		Human
Sponder M, Dangl D, Kampf S, Fritzer-Szekeres M, Strametz-Juranek J Exercise increases serum endostatin levels in female and male patients with diabetes and controls. Cardiovasc Diabetol, 2014-01-06;13(0):6. 2014-01-06 [PMID: 24393402] (Human)		Human
Battinelli , Elisabet, Markens , Beth A, Kulenthirarajan , Rajesh A, Machlus , Kellie R, Flaumenhaft , Robert, Italiano , Joseph E Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood, 2013-09-24;123(1):101-12. 2013-09-24 [PMID: 24065244] (Human)		Human
Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer. J Immunol, 2013-03-15;190(8):4420-30. 2013-03-15 [PMID: 23509357] (Mouse)		Mouse
Zheng , Lan, Zhang , Dongmei, Chen , Xianchen, Yang , Li, Wei , Yuquan, Zhao , Xia Antitumor activities of human placenta-derived mesenchymal stem cells expressing endostatin on ovarian cancer. PLoS ONE, 2012-07-24;7(7):e39119. 2012-07-24 [PMID: 22911684] (Human)		Human
Landt S, Mordelt K, Schwidde I, Barinoff J, Korlach S, Stoblen F, Lichtenegger W, Sehouli J, Kummel S Prognostic significance of the angiogenic factors angiogenin, endoglin and endostatin in cervical cancer. Anticancer Res., 2011-08-01;31(8):2651-5. 2011-08-01 [PMID: 21778318] (Human)		Human
Landt S, Heidecke H, Korlach S, Reuter C, Schwidde I, Barinoff J, Thill M, Sehouli J, Kummel S In vitro vascular tube formation testing as a tool for treatment individualisation in patients with cervical cancer. Anticancer Res., 2011-08-01;31(8):2609-15. 2011-08-01 [PMID: 21778312] (Human)		Human
Sun XD, Jeng L, Bolliet C, Olsen BR, Spector M Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials, 2008-12-06;30(6):1222-31. 2008-12-06 [PMID: 19059640] (Goat)		Goat
Mellon MJ, Bae KH, Steding CE, Jimenez JA, Kao C, Gardner TA Suppression of renal cell carcinoma growth and metastasis with sustained antiangiogenic gene therapy. Hum. Gene Ther., 2008-05-01;19(5):487-95. 2008-05-01 [PMID: 18507514] (Human)		Human
Holmes CE, Huang JC, Pace TR, Howard AB, Muss HB Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer. Clin. Cancer Res., 2008-05-15;14(10):3070-6. 2008-05-15 [PMID: 18483373] (Human)		Human
Bendrik C, Robertson J, Gauldie J, Dabrosin C Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo. Cancer Res., 2008-05-01;68(9):3405-12. 2008-05-01 [PMID: 18451168] (Human)		Human
Ohlund D, Ardnor B, Oman M, Naredi P, Sund M Expression pattern and circulating levels of endostatin in patients with pancreas cancer. Int. J. Cancer, 2008-06-15;122(12):2805-10. 2008-06-15 [PMID: 18360823] (Human)		Human
Li HL, Li S, Shao JY, Lin XB, Cao Y, Jiang WQ, Liu RY, Zhao P, Zhu XF, Zeng MS, Guan ZZ, Huang W Pharmacokinetic and pharmacodynamic study of intratumoral injection of an adenovirus encoding endostatin in patients with advanced tumors. Gene Ther., 2007-12-20;15(4):247-56. 2007-12-20 [PMID: 18097470] (Human)		Human
Perryman LA, Blair JM, Kingsley EA, Szymanska B, Ow KT, Wen VW, MacKenzie KL, Vermeulen PB, Jackson P, Russell PJ Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo. Biochem. Biophys. Res. Commun., 2006-05-11;345(3):1207-14. 2006-05-11 [PMID: 16723121] (Human)		Human
Ferrandina G, Ranelletti FO, Legge F, Salutari V, Martinelli E, Fattorossi A, Lorusso D, Zannoni G, Vellone V, Paglia A, Scambia G Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer. Clin. Cancer Res., 2006-04-01;12(7):2055-60. 2006-04-01 [PMID: 16609015] (Human)		Human
Furstenberger G, von Moos R, Lucas R, Thurlimann B, Senn HJ, Hamacher J, Boneberg EM Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br. J. Cancer, 2006-02-27;94(4):524-31. 2006-02-27 [PMID: 16450002] (Human)		Human
Show All 22 Publications. Collapse Publications.

Array DNST0

• Endostatin Antibodies
• Endostatin ELISA Kits
• Endostatin Proteins
• Endostatin Proteins and Enzymes
• Endostatin ELISAs