Human Endostatin DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using DY1098	Applications	Species
Zisman, D;Sabtan, H;Rahat, MM;Simanovich, E;Haddad, A;Gazitt, T;Feld, J;Slobodin, G;Kibari, A;Elias, M;Rahat, MA; Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S International journal of molecular sciences 2024-07-02 [PMID: 39000375] (Human)		Human
Alehagen, U;Alexander, J;Aaseth, JO;Larsson, A;Svensson, E;Opstad, TB; Effects of an Intervention with Selenium and Coenzyme Q10 on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial Cells 2023-07-04 [PMID: 37443807] (Human)		Human
J Jiang, X Cong, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog In Vitro Comparison of Lymphangiogenic Potential of Hypoxia Preconditioned Serum (HPS) and Platelet-Rich Plasma (PRP) International Journal of Molecular Sciences, 2023-01-19;24(3):. 2023-01-19 [PMID: 36768283] (Human)		Human
KN Lee, KH Park, YM Kim, I Cho, TE Kim Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid PLoS ONE, 2022-05-10;17(5):e0268291. 2022-05-10 [PMID: 35536791] (Human)		Human
S Hong, KH Park, YE Lee, JE Lee, YM Kim, E Joo, I Cho Antibody microarray analysis of amniotic fluid proteomes in women with cervical insufficiency and short cervix, and their association with pregnancy latency length PLoS ONE, 2022-02-07;17(2):e0263586. 2022-02-07 [PMID: 35130326] (Human)		Human
T Ruge, A Larsson, M Lipcsey, J Tydén, J Johansson, M Eriksson A Comparison between Endostatin and Conventional Biomarkers on 30-Day Mortality and Renal Replacement Therapy in Unselected Intensive Care Patients Biomedicines, 2021-11-03;9(11):. 2021-11-03 [PMID: 34829832] (Human)		Human
M Griffiths, J Yang, D Vaidya, M Nies, S Brandal, DD Ivy, F Hickey, K Wolter-War, ED Austin, M Mullen, MW Pauciulo, KA Lutz, EB Rosenzweig, R Hirsch, D Yung, WC Nichols, AD Everett Biomarkers of Pulmonary Hypertension Are Altered in Children With Down Syndrome and Pulmonary Hypertension The Journal of pediatrics, 2021-10-21;0(0):. 2021-10-21 [PMID: 34687693] (Human)		Human
HK Pihlstrøm, T Ueland, AE Michelsen, P Aukrust, F Gatti, C Hammarströ, M Kasprzycka, J Wang, G Haraldsen, G Mjøen, DO Dahle, K Midtvedt, IA Eide, A Hartmann, H Holdaas Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients PLoS ONE, 2020-12-16;15(12):e0243759. 2020-12-16 [PMID: 33326471] (Human)		Human
MA Rahat, M Safieh, E Simanovich, E Pasand, T Gazitt, A Haddad, M Elias, D Zisman The role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis Arthritis Res Ther, 2020-10-14;22(1):240. 2020-10-14 [PMID: 33054815] (Human)		Human
K Lashkari, GC Teague, U Beattie, J Betts, S Kumar, MM McLaughlin, FJ López Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration PLoS ONE, 2020-08-07;15(8):e0236283. 2020-08-07 [PMID: 32764794] (Human)		Human
YJ Park, SJ Woo, YM Kim, S Hong, YE Lee, KH Park Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants Invest. Ophthalmol. Vis. Sci., 2019-09-03;60(12):3813-3820. 2019-09-03 [PMID: 31525777] (Human)		Human
I Govorov, K Bremme, A Larsson, M Holmström, E Komlichenk, R Chaireti, M Mints Blood inflammatory and endothelial markers in women with von Willebrand disease PLoS ONE, 2019-01-10;14(1):e0210544. 2019-01-10 [PMID: 30629692] (Human)		Human
E Fernlund, T Gyllenhamm, R Jablonowsk, M Carlsson, A Larsson, J Ärnlöv, P Liuba Serum Biomarkers of Myocardial Remodeling and Coronary Dysfunction in Early Stages of Hypertrophic Cardiomyopathy in the Young Pediatr Cardiol, 2017-03-30;0(0):. 2017-03-30 [PMID: 28361263] (Human)		Human
Chatterjee M, Huang Z, Zhang W, Jiang L, Hultenby K, Zhu L, Hu H, Nilsson GP, Li N Distinct platelet packaging, release, and surface expression of proangiogenic and antiangiogenic factors on different platelet stimuli. Blood, 2011-02-17;117(14):3907-11. 2011-02-17 [PMID: 21330475] (Human)		Human
Peterson JE, Zurakowski D, Italiano JE Normal ranges of angiogenesis regulatory proteins in human platelets. Am. J. Hematol., 2010-07-01;85(7):487-93. 2010-07-01 [PMID: 20575035] (Human)		Human
Boneberg EM, Legler DF, Hoefer MM, Ohlschlegel C, Steininger H, Fuzesi L, Beer GM, Dupont-Lampert V, Otto F, Senn HJ, Furstenberger G Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer. Br. J. Cancer, 2009-08-18;101(4):605-14. 2009-08-18 [PMID: 19672262] (Human)		Human
Woo IS, Kim KA, Jeon HM, Hong SH, Rho SY, Koh SJ, Lee MA, Byun JH, Kang JH, Hong YS, Lee KS, Cho CS, Choi MG, Chung IS Pretreatment serum endostatin as a prognostic indicator in metastatic gastric carcinoma. Int. J. Cancer, 2006-12-15;119(12):2901-6. 2006-12-15 [PMID: 16998835] (Human)		Human
Show All 17 Publications. Collapse Publications.

Array DY1098

• Endostatin Antibodies
• Endostatin ELISA Kits
• Endostatin Proteins
• Endostatin Proteins and Enzymes
• Endostatin ELISAs