Human CCL21/6Ckine DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCL21, also known as 6Ckine, TCA-4, SLC, Exodus-2, and A21, is a homeostatic chemokine that signals through CCR7 or CXCR3. CCL21 is constitutively presented on initial lymphatic vessels, high endothelial venules (HEV), and lymph node dendritic cells (DC) where it promotes the docking of DC to lymphatic vessels and the retention of T cells by lymph node DC, resulting in T cell priming for activation. Its upregulation during chronic inflammation or tissue damage promotes fibrosis, inflammatory cytokine production, and neuropathic pain. The soluble chemokine is elevated in rheumatoid arthritis synovial fluid and in the serum of coronary artery disease patients.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using DY366	Applications	Species
W Alturaiki, H Alkadi, S Alamri, ME Awadalla, A Alfaez, A Mubarak, MA Alanazi, FQ Alenzi, BF Flanagan, B Alosaimi Association between the expression of Toll-like receptors, cytokines, and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 severity Heliyon, 2022-12-24;0(0):e12653. 2022-12-24 [PMID: 36589720] (Human)		Human
J Cao, EM Novoa, Z Zhang, WCW Chen, D Liu, GCG Choi, ASL Wong, C Wehrspaun, M Kellis, TK Lu High-throughput 5' UTR engineering for enhanced protein production in non-viral gene therapies Nature Communications, 2021-07-06;12(1):4138. 2021-07-06 [PMID: 34230498] (Human)		Human
X Guo, T Xu, J Zheng, X Cui, M Li, K Wang, M Su, H Zhang, K Zheng, C Sun, S Song, H Liu Accumulation of synovial fluid CD19+CD24hiCD27+ B cells was associated with bone destruction in rheumatoid arthritis Sci Rep, 2020-09-01;10(1):14386. 2020-09-01 [PMID: 32873834] (Human)		Human
J Bourland, J Fradette, FA Auger Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development Sci Rep, 2018-09-04;8(1):13191. 2018-09-04 [PMID: 30181613] (Human)		Human
L Strasser, HH Dang, H Schwarz, C Asam, F Ferreira, J Horejs-Hoe, CG Huber Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells Sci Rep, 2017-11-30;7(1):16638. 2017-11-30 [PMID: 29192156] (Human)		Human
J Lee, C Park, HJ Kim, YD Lee, ZH Lee, YW Song, HH Kim Stimulation of osteoclast migration and bone resorption by C-C chemokine ligands 19 and 21 Exp. Mol. Med., 2017-07-21;49(7):e358. 2017-07-21 [PMID: 28729639] (Human)		Human
Astrup E, Janardhanan J, Otterdal K, Ueland T, Prakash J, Lekva T, Strand O, Abraham O, Thomas K, Damas J, Mathews P, Mathai D, Aukrust P, Varghese G Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality. PLoS Negl Trop Dis, 2014-02-06;8(2):e2648. 2014-02-06 [PMID: 24516677] (Human)		Human
Pranzatelli , Michael, Tate , Elizabet, McGee , Nathan R, Travelstead , Anna L, Colliver , Jerry A, Ness , Jayne M, Ransohoff , Richard BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy. J Neuroinflammation, 2013-01-16;10(0):10. 2013-01-16 [PMID: 23324534] (Human)		Human
Vujanovic , Lazar, Ballard , Wenners, Thorne , Stephen, Vujanovic , Nikola L, Butterfield , Lisa H Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10. Oncoimmunology, 2012-07-01;1(4):448-457. 2012-07-01 [PMID: 22754763] (Human)		Human
Quesnel C, Piednoir P, Gelly J, Nardelli L, Garnier M, Lecon V, Lasocki S, Bouadma L, Philip I, Elbim C, Mentre F, Soler P, Crestani B, Dehoux M Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury. Crit. Care Med., 2012-01-01;40(1):21-8. 2012-01-01 [PMID: 21926612] (Human)		Human
Zimmer A, Luce S, Gaignier F, Nony E, Naveau M, Biola-Vidamment A, Pallardy M, Van Overtvelt L, Mascarell L, Moingeon P Identification of a New Phenotype of Tolerogenic Human Dendritic Cells Induced by Fungal Proteases from Aspergillus oryzae. J. Immunol., 2011-03-02;186(7):3966-76. 2011-03-02 [PMID: 21368225] (Human)		Human
Johnson LA, Jackson DG Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration. Int. Immunol., 2010-08-25;22(10):839-49. 2010-08-25 [PMID: 20739459] (Human)		Human
Toulza F, Nosaka K, Tanaka Y Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells. J. Immunol., 2010-06-04;185(1):183-9. 2010-06-04 [PMID: 20525891] (Human)		Human
Show All 13 Publications. Collapse Publications.

Array DY366

• CCL21/6Ckine Antibodies
• CCL21/6Ckine Lysate
• CCL21/6Ckine Proteins
• CCL21/6Ckine ELISAs
• CCL21/6Ckine Proteins and Enzymes