HSD3B1 Antibody (FDO66Q)

3A-hydroxysteroid dehydrogenase (HSD3B) is a bifunctional enzyme from 3-beta-HSD family that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid as well as ketosteroids, and is essential for the biosynthesis of all classes of hormonal steroids. HSD3B catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosteron. HSD3B is highly expressed in placenta, skin, mammary tissues etc and localize to ER/mitochondrion membranes as single-pass membrane protein wherein it plays critical role in lipid metabolism as well as steroid biosynthesis pathways. Among its different isoforms, HSD3B1 is abundantly expressed in human placenta and is implicated progesterone biosynthesis for the maintenance of pregnancy. HSD3B1 polymorphism has been linked to prostate cancer susceptibility, an increased risk of benign prostate hyperplasia, and essential hypertension.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Mouse, Rat, Bovine, Goat, Porcine, Sheep.

We have publications tested in 3 applications: ICC/IF, IHC-Fr, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB110-78644	Applications	Species
Zhang GM, Guo YX, Cheng CY et al. Arginine infusion rescues ovarian follicular development in feed-restricted Hu sheep during the luteal phase Theriogenology 2020-09-08 [PMID: 32932187] (WB, Sheep)	WB	Sheep
Kozubek A, Katarzynska-Banasik D, Grzegorzewska A et al. Nitrophenols are negative modulators of steroidogenesis in preovulatory follicles of the hen (Gallus domesticus) ovary: An in vitro and in vivo study Theriogenology 2020-07-01 [PMID: 32810793] (WB)	WB
Ganesan S, McGuire BC, Keating AF Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis Reprod. Toxicol. 2020-06-24 [PMID: 32592754] (ICC/IF, WB, Mouse)	ICC/IF, WB	Mouse
Bidne KL, Romoser MR, Ross JW et al. Heat stress during the luteal phase decreases luteal size but does not impact circulating progesterone in gilts J. Anim. Sci. 2019-08-02 [PMID: 31372640]
An SY, Zhang GM, Liu ZF, et al MiR-1197-3p regulates testosterone secretion in goat Leydig cells via targeting PPARGC1A Gene 2019-05-31 [PMID: 31158446] (WB, Goat)	WB	Goat
Palaniappan M, Menon KM. Luteinizing Hormone/Human Chorionic Gonadotropin-Mediated Activation of mTORC1 Signaling Is Required for Androgen Synthesis by Theca-Interstitial Cells Mol Endocrinol 2012-10-01 [PMID: 22827930] (WB, Rat)	WB	Rat
Mueller, UW et al. Isolation of fetal trophoblast cells from peripheral blood of pregnant women. Lancet;336(8709):197-200. 1990-07-28 [PMID: 1973769] (ICC/IF)	ICC/IF
Bidne KL. Investigating the ovarian response to endotoxemia. Thesis 1905-07-09 (WB, Porcine)	WB	Porcine
Zhang R, Kikuchi AT, Nakao T et al. Identification and functional characterization of microRNAs in rat Leydig cells during development from the progenitor to the adult stage Mol. Cell. Endocrinol. 2019-05-23 [PMID: 31129276] (WB, Rat)	WB	Rat
Zhang G M, Deng M T et al. Effects of NRF1 on steroidogenesis and apoptosis in goat luteinized granulosa cells. Reproduction 2017-01-08 [PMID: 28624767] (WB, Goat)	WB	Goat
Irving-Rodgers HF, Krupa M, Rodgers RJ. Cholesterol side-chain cleavage cytochrome P450 and 3beta-hydroxysteroid dehydrogenase expression and the concentrations of steroid hormones in the follicular fluids of different phenotypes of healthy and atretic bovine ovarian follicles. Biol Reprod;69(6):2022-8. 2003-12-01 [PMID: 12930727]
Irving-Rodgers HF, Bathgate RA, Ivell R, Domagalski R, Rodgers RJ. Dynamic changes in the expression of relaxin-like factor (INSL3), cholesterol side-chain cleavage cytochrome p450, and 3beta-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia. Biol Reprod;66(4):934-43. 2002-04-01 [PMID: 11906911] (IHC-Fr, Bovine)	IHC-Fr	Bovine
Show All 12 Publications. Collapse Publications.

Array NB110-78644

• HSD3B1 Antibodies
• HSD3B1 Lysate
• HSD3B1 Proteins