Histone H1.5 Antibody Summary
Immunogen |
This antibody was developed against Recombinant Protein corresponding to amino acids: ETATPAPVEKSPAKKKATKKAAG |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
HIST1H1B |
Purity |
Affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 1:200 - 1:500
- Immunohistochemistry-Paraffin 1:200 - 1:500
|
Application Notes |
For IHC-Paraffin, HIER pH 6 retrieval is recommended. |
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
PBS, pH 7.2, 40% glycerol |
Preservative |
0.02% Sodium Azide |
Purity |
Affinity purified |
Alternate Names for Histone H1.5 Antibody
Background
Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Histone H1.5 is a 207 amino acid long, 22 kDA protein encoded by the gene HIST1H1B (found on chromosome 6p22-p21.3) that lacks polyA tails and instead obtain palindromic termination elements. H1 histones are critical for the condensation of nucleosome chains into higher order structures. HIST1H1B has been investigated regarding breast cancer, measles, ataxia, t-cell leukemia, arthritis, alzheimer's diseases, lupus, and prostate cancer. It is active in apoptosis, histone modification, PKA signaling, and cell cycle chromosome condensation in prometaphase as it interacts with genes H3F3A, H3F3B, SIRT1, CDK2, and L3MNTL1.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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FAQs for Histone H1.5 Antibody (NBP3-17162) (0)
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