Glypican 4 Antibody (961609) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Glypican 4, also known as K-Glypican, is an approximately 220 kDa GPI-anchored heparan sulfate proteoglycan with a 60 kDa protein core (1, 2). It is expressed in brain, kidney, adrenal gland, and fat tissue (1, 3) and binds to basic FGF (2). Mature human Glypican 4 shares 97% and 96% amino acid (aa) sequence identity with mouse and rat Glypican 4, respectively. An alternative splice isoform lacks the N-terminal 70 aa including the signal peptide. In the developing brain, Glypican 4 is found in lateral ventricles surrounding the telencephalon, the dentate gyrus, proliferating neuroepithelial cells, and neural precursors (1, 2). It inhibits the dopaminergic differentiation of neurons (4). A 30 kDa cleaved form of Glypican 4 binds in cis to PTP sigma and contributes to excitatory synapse development and function (5). Glypican 4 is differentially expressed between adipose tissue depots (3). A soluble form can be released by adipocytes and circulates at elevated levels in obese patients with insulin resistance (3, 6). This form binds and enhances signaling through the Insulin R, and it also supports adipocyte differentiation (3). In zebrafish, Glypican 4 is required for cartilage formation and cardiomyocyte differentiation (7, 8).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB9195	Applications	Species
A Timpanaro, C Piccand, AC Uldry, PK Bode, D Dzhumashev, R Sala, M Heller, J Rössler, M Bernasconi Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma International Journal of Molecular Sciences, 2023-01-30;24(3):. 2023-01-30 [PMID: 36768928] (Flow Cytometry, Human)	Flow Cytometry	Human
L Huang, B Bockorny, I Paul, D Akshinthal, PO Frappart, O Gandarilla, A Bose, V Sanchez-Go, E Rouse, S Lehoux, N Pandell, C Lim, JG Clohessy, JE Grossman, RS Gonzalez, S Perea, G Daaboul, M Sawhney, SD Freedman, A Kleger, RD Cummings, A Emili, L Muthuswamy, M Hidalgo, S Muthuswamy PDX-derived organoids model in vivo drug response and secrete biomarkers JCI Insight, 2020-11-05;0(0):. 2020-11-05 [PMID: 32990680] (Western Blot, Human)	Western Blot	Human

Array MAB9195

• Glypican 4 Antibodies
• Glypican 4 ELISA Kits
• Glypican 4 Proteins
• Glypican 4 Proteins and Enzyme
• Glypican 4 ELISA